ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaph3via
DescriptionAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Antibiotic Resistanceamikacin
butirosin
gentamicin_b
isepamicin
kanamycin
neomycin
paromomycin
ribostamycin
Gene Ontology (GO)Molecular Function
aminoglycoside phosphotransferase activity [GO:0034071]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusAcinetobacter
Alcaligenes
Pseudomonas
NCBI CDD110623
88613: APH
Reference PubMed: 11083623
2) Martin P, et al. (1988) Nucleotide sequence of Acinetobacter baumannii aphA-6 gene: evolutionary and functional implications of sequence homologies with nucleotide-binding proteins, kinases and other aminoglycoside-modifying enzymes.. Mol Microbiol 2(5):615-25 PubMed: 2846986
 PubMed: 8385262