ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaph3vb
DescriptionAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Antibiotic Resistanceneomycin
paromomycin
ribostamycin
Gene Ontology (GO)Molecular Function
aminoglycoside phosphotransferase activity [GO:0034071]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusStreptomyces
NCBI CDD110623
88613: APH
Reference PubMed: 11083623
2) Thompson CJ, et al. (1983) Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases encoded by resistance plasmids.. Proc Natl Acad Sci U S A 80(17):5190-4 PubMed: 6310563
 PubMed: 8385262