ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaph3iiia
DescriptionAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Antibiotic Resistanceamikacin
butirosin
gentamincin_b
isepamicin
kanamycin
lividomycin
neomycin
paromomycin
ribostamycin
Gene Ontology (GO)Molecular Function
aminoglycoside phosphotransferase activity [GO:0034071]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusBacillus
Bacteroides
Campylobacter
Enterococcus
Escherichia
other sequences
Roseburia
Staphylococcus
Streptococcus
COGCOG3231
Description: Aminoglycoside phosphotransferase
Function: Translation, ribosomal structure and biogenesis;

NCBI CDD110623
88613: APH
Reference PubMed: 11083623
2) Trieu-Cuot P, et al. (1983) Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III.. Gene 23(3):331-41 PubMed: 6313476
 PubMed: 8385262