ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaph3ib
DescriptionAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Antibiotic Resistancegentamincin_b
kanamycin
lividomycin
neomycin
paromomycin
ribostamycin
Gene Ontology (GO)Molecular Function
aminoglycoside phosphotransferase activity [GO:0034071]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusEscherichia
NCBI CDD110623
88613: APH
Reference PubMed: 11083623
2) Pansegrau W, et al. (1987) Nucleotide sequence of the kanamycin resistance determinant of plasmid RP4: homology to other aminoglycoside 3'-phosphotransferases.. Plasmid 18(3):193-204 PubMed: 2832861
 PubMed: 8385262