ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaph3ia
DescriptionAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Antibiotic Resistancegentamincin_b
kanamycin
lividomycin
neomycin
paromomycin
ribostamycin
Gene Ontology (GO)Molecular Function
aminoglycoside phosphotransferase activity [GO:0034071]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusAcetobacter
Acinetobacter
Actinobacillus
Avibacterium
Bacillus
Brugia
Burkholderia
Campylobacter
Citrobacter
Corynebacterium
Entamoeba
Enterobacter
Escherichia
Klebsiella
Kluyveromyces
Neisseria
Oceanicaulis
other sequences
Photobacterium
Pichia
Proteus
Providencia
Salmonella
Serratia
Shigella
Yersinia
COGCOG3231
Description: Aminoglycoside phosphotransferase
Function: Translation, ribosomal structure and biogenesis;

NCBI CDD112392
110623
88613: APH
Reference PubMed: 11083623
2) Terawaki Y, et al. (1968) Temperature sensitivity of cell growth in Escherichia coli associated with the temperature sensitive R(KM) factor.. Nature 219(5151):284-5 PubMed: 4876466
 PubMed: 8385262