ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaph33ia
DescriptionAminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Antibiotic Resistancestreptomycin
Gene Ontology (GO)Molecular Function
aminoglycoside phosphotransferase activity [GO:0034071]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusStreptomyces
NCBI CDD88613: APH
Reference1) Shinkawa H, et al. (1987) The nucleotide sequence of a streptomycin streptomycin phosphotransferase (streptomycin kinase) [corrected] gene from a streptomycin producer.. J Gen Microbiol 133(5):1289-96 PubMed: 2821169
 PubMed: 11083623
 PubMed: 8385262