ARDB-Antibiotic Resistance Genes Database

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Resistance Typeant4iia
DescriptionAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Antibiotic Resistanceamikacin
isepamicin
tobramycin
Gene Ontology (GO)Molecular Function
aminoglycoside nucleotidyltransferase activity [GO:0034068]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusPseudomonas
NCBI CDD140897
Reference1) Shaw KJ, et al. (1993) Nucleotide sequence analysis and DNA hybridization studies of the ant(4')-IIa gene from Pseudomonas aeruginosa.. Antimicrob Agents Chemother 37(4):708-14 PubMed: 8494365
 PubMed: 11083623
 PubMed: 8385262