ARDB-Antibiotic Resistance Genes Database

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Resistance Typeant2ia
DescriptionAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Antibiotic Resistancedibekacin
gentamicin
kanamycin
sisomicin
tobramycin
Gene Ontology (GO)Molecular Function
aminoglycoside nucleotidyltransferase activity [GO:0034068]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusAchromobacter
Acinetobacter
Brevundimonas
Burkholderia
Chryseobacterium
Citrobacter
Corynebacterium
Elizabethkingia
Enterobacter
Escherichia
Klebsiella
Morganella
Neisseria
Proteus
Pseudomonas
Riemerella
Salmonella
Serratia
Shigella
Stenotrophomonas
Vibrio
Yersinia
NCBI CDD140897
119226
Reference PubMed: 11083623
2) Cameron FH, et al. (1986) Nucleotide sequence of the AAD(2'') aminoglycoside adenylyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538-1 and dhfrII in R388.. Nucleic Acids Res 14(21):8625-35 PubMed: 3024112
 PubMed: 8385262