ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaadd
DescriptionAminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Antibiotic Resistancekanamycin
tobramycin
Gene Ontology (GO)Molecular Function
aminoglycoside nucleotidyltransferase activity [GO:0034068]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusBacillus
Geobacillus
Staphylococcus
COGCOG1669
Description: Predicted nucleotidyltransferases
Function: General function prediction only;

NCBI CDD71267: KNTase_C
140897
Reference PubMed: 11083623
2) Matsumura M, et al. (1984) Enzymatic and nucleotide sequence studies of a kanamycin-inactivating enzyme encoded by a plasmid from thermophilic bacilli in comparison with that encoded by plasmid pUB110.. J Bacteriol 160(1):413-20 PubMed: 6090428
 PubMed: 8385262