ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaac6ie
DescriptionAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Antibiotic Resistanceamikacin
dibekacin
isepamicin
netilmicin
sisomicin
tobramycin
Gene Ontology (GO)Molecular Function
aminoglycoside N-acetyltransferase activity [GO:0034069]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusEnterococcus
Macrococcus
Staphylococcus
COGCOG1670
Description: Acetyltransferases, including N-acetylases of ribosomal proteins
Function: Translation, ribosomal structure and biogenesis;

NCBI CDD31856: RimL
119390
88612: cd05120
110623
142329
Reference PubMed: 11083623
2) Ferretti JJ, et al. (1986) Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities.. J Bacteriol 167(2):631-8 PubMed: 3015884
 PubMed: 8385262