ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaac3iii
DescriptionAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Antibiotic Resistancedibekacin
gentamicin
kanamycin
lividomycin
neomycin
paromomycin
sisomicin
tobramycin
Gene Ontology (GO)Molecular Function
aminoglycoside N-acetyltransferase activity [GO:0034069]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusPseudomonas
NCBI CDD120344
Reference1) Vliegenthart JS, et al. (1991) Nucleotide sequence of the aacC3 gene, a gentamicin resistance determinant encoding aminoglycoside-(3)-N-acetyltransferase III expressed in Pseudomonas aeruginosa but not in Escherichia coli.. Antimicrob Agents Chemother 35(5):892-7 PubMed: 1649572
 PubMed: 11083623
 PubMed: 8385262