ARDB-Antibiotic Resistance Genes Database

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Resistance Typeaac3iia
DescriptionAminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Antibiotic Resistancedibekacin
gentamicin
netilmicin
sisomicin
tobramycin
Gene Ontology (GO)Molecular Function
aminoglycoside N-acetyltransferase activity [GO:0034069]


Biological Process
aminoglycoside resistance [AR:0000016]
drug enzymatic destruction [AR:0001004]
Found in GenusAchromobacter
Acinetobacter
Actinobacillus
Alphaproteobacteria
Citrobacter
Enterobacter
Escherichia
Homo
Klebsiella
Pseudomonas
Salmonella
NCBI CDD120344
Reference1) Allmansberger R, et al. (1985) Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide sequences of three AAC(3)-III genes and evolutionary aspects.. Mol Gen Genet 198(3):514-20 PubMed: 3892230
 PubMed: 11083623
 PubMed: 8385262