ARDB-Antibiotic Resistance Genes Database

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Resistance TypeMefA
DescriptionMajor facilitator superfamily transporter, Macrolide-Lincosamide-Streptogramin B efflux pump.
Antibiotic Resistancemacrolide
Gene Ontology (GO)Molecular Function
efflux transmembrane transporter activity [GO:0015562]


Biological Process
major facilitator superfamily (MFS) drug efflux [AR:0010002]
lincomycin resistance [AR:0000046]
Found in GenusArcanobacterium
Bacteroides
Clostridium
Enterococcus
Fusobacterium
Gemella
Granulicatella
Neisseria
Staphylococcus
Streptococcus
COGCOG477
Description: Permeases of the major facilitator superfamily
Function: Carbohydrate transport and metabolism; Amino acid transport and metabolism; Inorganic ion transport and metabolism; General function prediction only;

NCBI CDD129978
119392
Reference1) Clancy J, et al. (1996) Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes.. Mol Microbiol 22(5):867-79 PubMed: 8971709
 PubMed: 10582867