ARDB-Antibiotic Resistance Genes Database

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Resistance TypeErmS
DescriptionrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.
Antibiotic Resistancelincosamide
macrolide
streptogramin_b
Gene Ontology (GO)Molecular Function
rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]


Biological Process
roxithromycin resistance [AR:0000027]
glycylcycline resistance [AR:0000042]
erythromycin resistance [AR:0000006]
drug target modification [AR:0001001]
Found in GenusStreptomyces
NCBI CDD142332
Reference1) Kamimiya S, et al. (1988) Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.. J Bacteriol 170(4):1800-11 PubMed: 3127381