ARDB-Antibiotic Resistance Genes Database

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Resistance TypeErmC
DescriptionrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.
Antibiotic Resistancelincosamide
macrolide
streptogramin_b
Gene Ontology (GO)Molecular Function
rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]


Biological Process
roxithromycin resistance [AR:0000027]
glycylcycline resistance [AR:0000042]
erythromycin resistance [AR:0000006]
drug target modification [AR:0001001]
Found in GenusBacillus
Lactobacillus
Neisseria
Staphylococcus
NCBI CDD140359
142332
100107
Reference1) Gryczan TJ, et al. (1980) Conformational alteration of mRNA structure and the posttranscriptional regulation of erythromycin-induced drug resistance.. Nucleic Acids Res 8(24):6081-97 PubMed: 6162157