ARDB-Antibiotic Resistance Genes Database

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Resistance TypeErmA
DescriptionrRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.
Antibiotic Resistancelincosamide
macrolide
streptogramin_b
Gene Ontology (GO)Molecular Function
rRNA (adenine-N6-)-methyltransferase activity [GO:0008988]


Biological Process
roxithromycin resistance [AR:0000027]
glycylcycline resistance [AR:0000042]
erythromycin resistance [AR:0000006]
drug target modification [AR:0001001]
Found in GenusHelcococcus
Staphylococcus
Streptococcus
COGCOG30
Description: Dimethyladenosine transferase (rRNA methylation)
Function: Translation, ribosomal structure and biogenesis;

NCBI CDD142332
Reference1) Murphy E, et al. (1985) Transposon Tn554: complete nucleotide sequence and isolation of transposition-defective and antibiotic-sensitive mutants.. EMBO J 4(12):3357-65 PubMed: 3004956