ARDB-Antibiotic Resistance Genes Database

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OrganismEscherichia coli K12
Database LinkNCBI Taxon ID: 83333
NCBI Genome Project ID: 225

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_000913U000964639675


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
NP_418757chromosomeBAE78330100.00%mdtm%acriflavine chloramphenicol norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_416758chromosomeAAL23678100.00%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
NP_417970chromosomeBAE77781100.00%mdte%doxorubicin erythromycin mdtf tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_414593chromosomeABF02332100.00%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
NP_418574chromosomeBAE78154100.00%bl1_ec%cephalosporin Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
NP_415075chromosomeBAE76318100.00%emre%aminoglycoside emrd Multidrug resistance efflux pump.
NP_418505chromosomeAAD1346497.66%mdto%acriflavine puromycin t_chloride mdtn mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_418504chromosomeBAE7808297.13%mdtp%acriflavine puromycin t_chloride mdtn mdto Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_418166chromosomeBAE7758096.93%mdtl%chloramphenicol Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_417529chromosomeBAE7710896.88%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
NP_417507chromosomeAAA6920396.83%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_415399chromosomeBAB6454196.77%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_414995chromosomeBAE7624194.66%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_415400chromosomeBAB6454293.98%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_417971chromosomeBAE7778093.06%mdtf%doxorubicin erythromycin mdte tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_025307chromosomeABG6961591.03%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_415571chromosomeBAA3585190.93%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_415583chromosomeABG6907089.55%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_414996chromosomeBAE7624289.42%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_418506chromosomeBAE7808481.92%mdtn%acriflavine puromycin t_chloride mdto mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_418129chromosomeAAC7669675.63%emrd%emre Multidrug resistance efflux pump.
NP_417732chromosomeYP_00157146174.73%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_415011chromosomeYP_00147737770.62%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_416965chromosomeNP_75251464.38%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_417731chromosomeCAC3572462.67%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_415012chromosomeYP_00147737858.06%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_414876chromosomeYP_00138962146.15%vatb%streptogramin_a Virginiamycin A acetyltransferase, which can inactivate the target drug.
NP_414992chromosomeAAK8871245.10%catb1%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
NP_415635chromosomeYP_00145376044.75%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_415028chromosomeYP_00145376042.92%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_416478chromosomeABB5334940.28%vanrb%vancomycin vanb vanhb vansb vanwb vanxb vanyb VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
NP_415363chromosomeZP_0092526940.05%%
Below Similarity Cutoff Genes
NP_414773chromosomeYP_00144437668.00%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
NP_415168chromosomeYP_00145266259.54%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_414691chromosomeP5729653.02%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_417855chromosomeYP_00129003352.02%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_417675chromosomeYP_00129003344.35%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)