ARDB-Antibiotic Resistance Genes Database

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OrganismSaccharopolyspora erythraea NRRL 2338
Database LinkNCBI Taxon ID: 405948
NCBI Genome Project ID: 18489

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_009142AM4202938212805


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
YP_001103000chromosomeCAB6000189.93%erme%lincosamide macrolide streptogramin_b rRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.
YP_001105802chromosomeBAA7861977.65%aac3x%aminoglycoside Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
YP_001105803chromosomeCAF3332571.34%aac3viii%neomycin ribostamycin Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
YP_001108102chromosomeCAA0738161.22%aph6ib%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_001108746chromosomeEBA4353655.37%mfpa%fluoroquinolone Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
YP_001106477chromosomeYP_08993249.14%bl2a_iii2%penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_001103621chromosomeQ5951747.72%bl2b_tle%cephalosporin penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_001109334chromosomeYP_00143854145.81%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001105583chromosomeAAC6167045.20%vgbb%streptogramin_b Streptogramin B Lyase, which can deactivate the target drug by hydrolysis.
YP_001109185chromosomeABB5336844.57%vanrb%vancomycin vanb vanhb vansb vanwb vanxb vanyb VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_001105394chromosomeYP_00117612844.50%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001106405chromosomeCAA3747744.17%otra%tetracycline Ribosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.
YP_001105882chromosomeAAG2169542.44%vate%streptogramin_a Virginiamycin A acetyltransferase, which can inactivate the target drug.
YP_001109006chromosomeABL0513242.35%mfpa%fluoroquinolone Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
YP_001105107chromosomeAAC1577542.19%otrb%tetracycline Major facilitator superfamily transporter, tetracycline efflux pump.
YP_001109297chromosomeAAN8081141.38%emre%aminoglycoside emrd Multidrug resistance efflux pump.
YP_001104993chromosomeYP_00158879341.33%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001105968chromosomeAAM0985041.12%vanhd%teicoplanin vancomycin vand vanrd vansd vanxd vanyd VanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_001109367chromosomeYP_00133457840.59%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001105543chromosomeAAL2744540.49%vanre%vancomycin vane vanse vante vanxye VanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_001107765chromosomeBAA0294540.40%tmrb%tunicamycin Mechanism unknown.
YP_001102664chromosomeAAD0403240.19%otrb%tetracycline Major facilitator superfamily transporter, tetracycline efflux pump.
Below Similarity Cutoff Genes
YP_001103181chromosomeP0845741.46%sta80%streptothricin Streptothricin acetyltransferase (STAT).