ARDB-Antibiotic Resistance Genes Database

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OrganismYersinia pestis Nepal516
Database LinkNCBI Taxon ID: 377628
NCBI Genome Project ID: 16646

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
plasmid pMTNC_008118CP000306100918
plasmid pPCPNC_008119CP00030710778
chromosomeNC_008149CP0003054534590


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
YP_646298chromosomeQ66EQ899.63%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
YP_646441chromosomeCAL1932695.59%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
YP_646927chromosomeYP_00140199495.03%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_646889chromosomeCAL2172891.90%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_646928chromosomeCAL2169389.60%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_647803chromosomeYP_00146360271.74%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
YP_646890chromosomeYP_15144469.66%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_647775chromosomeYP_00145324769.52%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_648543chromosomeYP_00145376068.15%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_648544chromosomeYP_00157104267.40%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_646453chromosomeBAB3734667.39%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_647272chromosomeYP_00133412564.54%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_647447chromosomeYP_00143836863.82%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_646537chromosomeYP_00143887455.34%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_647721chromosomeBAB3503751.82%emre%aminoglycoside emrd Multidrug resistance efflux pump.
YP_647216chromosomeAAZ9883650.79%vansd%teicoplanin vancomycin vand vanhd vanrd vanxd vanyd VanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_647312chromosomeYP_00145376050.07%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_646536chromosomeYP_00117567848.47%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_646538chromosomeZP_0164597044.64%%
YP_647934chromosomeYP_00145376044.29%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_648409chromosomeYP_00117612843.58%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_648038chromosomeQ83LR742.47%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_648559chromosomeYP_00133457842.06%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_649242chromosomeABS7365441.25%ykkd%na_antimicrobials ykkc Small Multidrug Resistance (SMR) protein family. Multidrug resistance efflux pump, which consists of two proteins.
YP_648203chromosomeYP_00143854140.76%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_647313chromosomeYP_00133457740.74%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_646942chromosomeYP_00145376040.18%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Below Similarity Cutoff Genes
YP_646800chromosomeBAC5893663.82%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
YP_647020chromosomeP7487257.81%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_646629chromosomeP5729650.93%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_649848chromosomeYP_00129003348.15%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)