ARDB-Antibiotic Resistance Genes Database

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OrganismEscherichia coli 536
Database LinkNCBI Taxon ID: 362663
NCBI Genome Project ID: 16235

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_008253CP0002474938920


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
YP_669772chromosomeABF04122100.00%emre%aminoglycoside emrd Multidrug resistance efflux pump.
YP_671489chromosomeABG71588100.00%mdte%doxorubicin erythromycin mdtf tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_672241chromosomeABG72340100.00%bl1_ec%cephalosporin Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_670193chromosomeABG70292100.00%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
YP_667994chromosomeABG68095100.00%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
YP_668809chromosomeABG68908100.00%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_672169chromosomeABG7226898.24%mdto%acriflavine puromycin t_chloride mdtn mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_672168chromosomeABG7226797.13%mdtp%acriflavine puromycin t_chloride mdtn mdto Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_671782chromosomeABG7188196.93%mdtl%chloramphenicol Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_671031chromosomeABF0515996.88%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
YP_671011chromosomeYP_54244796.83%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_668451chromosomeABG6855294.66%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_671490chromosomeABG7158994.50%mdtf%doxorubicin erythromycin mdte tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_668810chromosomeABG6890993.98%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_669516chromosomeABG6961591.03%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_668960chromosomeABG6905990.93%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_668452chromosomeZP_0092165489.78%%
YP_668971chromosomeABG6907089.55%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_672170chromosomeABG7226983.97%mdtn%acriflavine puromycin t_chloride mdto mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_671751chromosomeABG7185075.76%emrd%emre Multidrug resistance efflux pump.
YP_671241chromosomeCAL1313774.81%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_668467chromosomeYP_00147737772.81%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_670372chromosomeNP_75251465.35%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_671240chromosomeCAC3572464.53%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_668468chromosomeYP_00147737858.06%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_669257chromosomeYP_00133412551.84%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_669256chromosomeYP_00117567851.38%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_668347chromosomeYP_00138962146.15%vatb%streptogramin_a Virginiamycin A acetyltransferase, which can inactivate the target drug.
YP_669024chromosomeYP_00145376045.81%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_668490chromosomeYP_00145376045.27%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_668448chromosomeAAK8871245.10%catb1%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
YP_668489chromosomeYP_00143854143.94%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_669804chromosomeABB5334940.28%vanrb%vancomycin vanb vanhb vansb vanwb vanxb vanyb VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_669258chromosomeBAA2869440.08%oprm%aminoglycoside beta_lactam fluoroquinolone tetracycline tigecycline mexa mexb mexj mexk mexv mexw mexx mexy Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_668774chromosomeZP_0092526940.05%%
Below Similarity Cutoff Genes
YP_668202chromosomeYP_00144437667.33%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
YP_668592chromosomeYP_00145266259.54%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_668098chromosomeP5729653.02%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_671359chromosomeYP_00129003352.02%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_671179chromosomeYP_00129003344.35%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)