ARDB-Antibiotic Resistance Genes Database

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OrganismEscherichia coli E24377A
Database LinkNCBI Taxon ID: 331111
NCBI Genome Project ID: 13960

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
plasmid pETEC_80NC_009786CP00079579237
plasmid pETEC_35NC_009787CP00079634367
plasmid pETEC_73NC_009788CP00079770609
plasmid pETEC_6NC_009789CP0007986199
plasmid pETEC_74NC_009790CP00079974224
plasmid pETEC_5NC_009791CP0008015033
chromosomeNC_009801CP0008004979619


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
YP_001461223chromosomeYP_001461223100.00%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
YP_001463602chromosomeYP_001463602100.00%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
YP_001464982chromosomeBAE77781100.00%mdte%doxorubicin erythromycin mdtf tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001465866chromosomeYP_001465866100.00%mdtm%acriflavine chloramphenicol norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001451542plasmid pETEC_6ABS71064100.00%aph33ib%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_001461939chromosomeYP_001461939100.00%emre%aminoglycoside emrd Multidrug resistance efflux pump.
YP_001451541plasmid pETEC_6ZP_0197408399.50%aph6id%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_001465585chromosomeYP_00146558597.66%mdto%acriflavine puromycin t_chloride mdtn mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001465652chromosomeBAE7815497.35%bl1_ec%cephalosporin Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_001465584chromosomeYP_00146086897.13%mdtp%acriflavine puromycin t_chloride mdtn mdto Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001465194chromosomeYP_00146519496.93%mdtl%chloramphenicol Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001464517chromosomeABF0515996.88%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
YP_001462076chromosomeYP_00145771996.77%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001461647chromosomeBAE7624194.66%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001464983chromosomeYP_00146498394.50%mdtf%doxorubicin erythromycin mdte tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001451543plasmid pETEC_6ABG5683194.10%sul2%sulfonamide Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
YP_001464496chromosomeAAA6920393.54%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001462958chromosomeYP_00146295891.03%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001462285chromosomeBAA3585190.93%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001462299chromosomeABG6907089.55%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001461648chromosomeBAE7624289.42%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001465586chromosomeYP_00146558681.05%mdtn%acriflavine puromycin t_chloride mdto mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001465157chromosomeAAC7669675.63%emrd%emre Multidrug resistance efflux pump.
YP_001464740chromosomeYP_00157146174.73%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001461667chromosomeYP_00147737772.99%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_001463792chromosomeNP_75251464.09%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001464739chromosomeCAC3572462.67%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001461668chromosomeYP_00147737858.56%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_001461645chromosomeAAK8871245.10%catb1%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
YP_001462350chromosomeYP_00145376044.75%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001461684chromosomeYP_00145376042.92%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001463269chromosomeABB5334940.28%vanrb%vancomycin vanb vanhb vansb vanwb vanxb vanyb VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_001464270chromosomeP2525640.26%tlrc%lincosamide macrolide streptogramin_b ABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump.
YP_001462039chromosomeZP_0092526940.05%%
Below Similarity Cutoff Genes
YP_001461426chromosomeYP_00144437668.00%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
YP_001461803chromosomeYP_00145266259.54%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_001461319chromosomeP5729653.02%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_001464850chromosomeYP_00129003352.02%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_001464686chromosomeYP_00129003344.35%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)