ARDB-Antibiotic Resistance Genes Database

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OrganismShigella sonnei Ss046
Database LinkNCBI Taxon ID: 300269
NCBI Genome Project ID: 13151

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_007384CP0000384825265
plasmid pSS_046NC_007385CP000039214396
plasmid pSS046_spANC_009345CP0006418401
plasmid pSS046_spBNC_009346CP0006425153
plasmid pSS046_spCNC_009347CP0006432101


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
YP_309089chromosomeABF02332100.00%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
YP_311196chromosomeYP_311196100.00%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
YP_310895chromosomeAAN80811100.00%emre%aminoglycoside emrd Multidrug resistance efflux pump.
YP_001139955plasmid pSS046_spAABS71064100.00%aph33ib%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_001139956plasmid pSS046_spAABS71065100.00%aph6id%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_312360chromosomeBAE77781100.00%mdte%doxorubicin erythromycin mdtf tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_312670chromosomeYP_00148144299.62%ant3ia%spectinomycin streptomycin Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
YP_313059chromosomeBAE7815498.41%bl1_ec%cephalosporin Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_312992chromosomeYP_31299298.10%mdto%acriflavine puromycin t_chloride mdtn mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_312991chromosomeYP_00146086897.13%mdtp%acriflavine puromycin t_chloride mdtn mdto Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_312344chromosomeQ31UW496.93%mdtl%chloramphenicol Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_312012chromosomeQ3YXI596.88%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
YP_311992chromosomeAAA6920396.83%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_309842chromosomeYP_00145771996.77%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_309460chromosomeYP_30946094.66%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_312359chromosomeYP_00146498394.50%mdtf%doxorubicin erythromycin mdte tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001139954plasmid pSS046_spAABG5683194.10%sul2%sulfonamide Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
YP_309843chromosomeQ3Z3Q493.98%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001139953plasmid pSS046_spAAAN0670791.51%teta%tetracycline Major facilitator superfamily transporter, tetracycline efflux pump.
YP_310429chromosomeABG6961591.03%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_310046chromosomeQ3Z35189.55%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_309461chromosomeYP_30946189.42%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_310028chromosomeBAA3585189.08%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_312993chromosomeZP_0073036981.92%%
YP_312412chromosomeBAB3803775.76%emrd%emre Multidrug resistance efflux pump.
YP_309476chromosomeYP_00147737772.81%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_311414chromosomeNP_75251464.19%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_312213chromosomeCAC3572462.67%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_309479chromosomeYP_00147737860.97%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_309457chromosomeAAK8871245.10%catb1%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
YP_310097chromosomeYP_00145376044.75%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_309495chromosomeYP_00145376042.92%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Below Similarity Cutoff Genes
YP_309298chromosomeYP_00144437668.00%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
YP_309590chromosomeYP_00145266259.38%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_309189chromosomeP5729653.02%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_312319chromosomeYP_00129003352.39%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_312164chromosomeYP_00129003344.35%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)