ARDB-Antibiotic Resistance Genes Database

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OrganismKlebsiella pneumoniae subsp. pneumoniae MGH 78578
Database LinkNCBI Taxon ID: 272620
NCBI Genome Project ID: 31

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_009648CP0006475315120
plasmid pKPN3NC_009649CP000648175879
plasmid pKPN4NC_009650CP000649107576
plasmid pKPN5NC_009651CP00065088582
plasmid pKPN6NC_009652CP0006514259
plasmid pKPN7NC_009653CP0006523478


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
YP_001338790plasmid pKPN5YP_001338790100.00%aph6id%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_001338660plasmid pKPN4ABL09147100.00%bl2be_shv2%e_cephalosporin monobactam n_cephalosporin penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_001337087chromosomeYP_001337087100.00%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
YP_001338810plasmid pKPN5AAF61485100.00%sul1%sulfonamide Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
YP_001338668plasmid pKPN4ABA54975100.00%aac6ib%amikacin dibekacin isepamicin netilmicin sisomicin tobramycin Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
YP_001335268chromosomeABI20752100.00%bl2be_shv2%e_cephalosporin monobactam n_cephalosporin penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_001338844plasmid pKPN5YP_001338844100.00%cata1%chloramphenicol Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
YP_001338804plasmid pKPN5BAF42018100.00%aph3ia%gentamincin_b kanamycin lividomycin neomycin paromomycin ribostamycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_001333738chromosomeYP_001333738100.00%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
YP_001338814plasmid pKPN5YP_001338814100.00%ant2ia%dibekacin gentamicin kanamycin sisomicin tobramycin Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
YP_001338789plasmid pKPN5YP_00109637999.63%aph33ib%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_001338669plasmid pKPN4YP_00148144299.62%ant3ia%spectinomycin streptomycin Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
YP_001335662chromosomeYP_00133566297.37%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001334125chromosomeYP_00133412595.99%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001338671plasmid pKPN4BAF6341895.10%bl2b_tem1%cephalosporin_i cephalosporin_ii penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_001338868plasmid pKPN5BAF6341895.10%bl2b_tem1%cephalosporin_i cephalosporin_ii penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_001334577chromosomeYP_00133457794.34%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001337075chromosomeYP_00133707594.11%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001338793plasmid pKPN5ABG5683194.10%sul2%sulfonamide Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
YP_001334126chromosomeYP_00133412691.18%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001334578chromosomeYP_00133457890.25%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001338812plasmid pKPN5YP_00133881287.59%cml_e180%chloramphenicol Major facilitator superfamily transporter, chloramphenicol efflux pump.
YP_001334739chromosomeYP_00133473985.07%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001334730chromosomeYP_00133473083.58%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001337728chromosomeYP_00133772881.46%emrd%emre Multidrug resistance efflux pump.
YP_001334140chromosomeYP_00147737778.65%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_001337499chromosomeYP_00146360277.63%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
YP_001337332chromosomeABX6846177.13%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001338866plasmid pKPN5BAF4202575.89%tetd%tetracycline Major facilitator superfamily transporter, tetracycline efflux pump.
YP_001338372chromosomeQ5641572.06%fosa%fosfomycin Glutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin
YP_001338380chromosomeCAD0336371.57%mdtm%acriflavine chloramphenicol norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001337331chromosomeCAC3572469.32%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001334141chromosomeYP_00147737869.03%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_001337770chromosomeYP_00145166968.66%mdtl%chloramphenicol Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001336443chromosomeABX6846164.67%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001334007chromosomeYP_00133473061.94%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001335752chromosomeCAD0336358.38%mdtm%acriflavine chloramphenicol norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_001336925chromosomeQ83P8657.66%mdtn%acriflavine puromycin t_chloride mdto mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001336606chromosomeYP_28702654.62%ceob%chloramphenicol ceoa opcm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001335722chromosomeCAJ7784453.85%adeb%aminoglycoside chloramphenicol adea adec Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001337690chromosomeYP_00117567752.40%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001337689chromosomeYP_00145423152.38%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001336927chromosomeBAE7808248.15%mdtp%acriflavine puromycin t_chloride mdtn mdto Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001338811plasmid pKPN5BAE7631846.00%emre%aminoglycoside emrd Multidrug resistance efflux pump.
YP_001336776chromosomeYP_00133457844.59%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001334777chromosomeYP_00145376044.55%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001336605chromosomeYP_00134810543.73%mexe%chloramphenicol fluoroquinolone mexf oprn Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_001337691chromosomeZP_0164597043.65%%
YP_001334540chromosomeZP_0072985043.38%%
YP_001336213chromosomeYP_00133457842.51%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001336068chromosomeYP_00143854141.77%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001334504chromosomeYP_00158879340.79%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001334154chromosomeYP_00145376040.64%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_001333980chromosomeABG6890940.09%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Below Similarity Cutoff Genes
YP_001335476chromosomeYP_00158749673.23%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_001333933chromosomeYP_00144437667.11%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
YP_001334347chromosomeYP_00145266258.39%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_001337421chromosomeYP_00129003353.18%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_001333854chromosomeP5729652.81%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_001337277chromosomeYP_00129003341.27%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)