ARDB-Antibiotic Resistance Genes Database

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OrganismBurkholderia xenovorans LB400
Database LinkNCBI Taxon ID: 266265
NCBI Genome Project ID: 254

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosome 1NC_007951CP0002704895836
chromosome 2NC_007952CP0002713363523
chromosome 3NC_007953CP0002721471779


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
YP_554454chromosome 2YP_55445490.95%ceob%chloramphenicol ceoa opcm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_558134chromosome 1YP_00158335071.91%ceob%chloramphenicol ceoa opcm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_554455chromosome 2ZP_0156388570.46%%
YP_554453chromosome 2ZP_0156388765.97%%
YP_560277chromosome 1YP_00147735862.42%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_558135chromosome 1ZP_0156388561.49%%
YP_558133chromosome 1YP_00158335160.17%opcm%chloramphenicol ceoa ceob Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_559665chromosome 1CAL2169360.05%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
YP_557537chromosome 1P2525659.46%tlrc%lincosamide macrolide streptogramin_b ABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump.
YP_558632chromosome 1YP_85336155.72%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
YP_555047chromosome 2AAA7339253.47%aph6ic%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
YP_557030chromosome 1ABG6809553.21%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
YP_553721chromosome 2AAY9331552.62%bl1_pse%cephalosporin Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_560278chromosome 1EAZ6096449.01%mexa%aminoglycoside beta_lactam fluoroquinolone tetracycline tigecycline mexb oprm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_553397chromosome 2CAF3162348.39%dfra22%trimethoprim Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
YP_557319chromosome 1AAA8687147.06%vatb%streptogramin_a Virginiamycin A acetyltransferase, which can inactivate the target drug.
YP_553675chromosome 2YP_00133457844.91%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_558046chromosome 1YP_34848844.86%mexd%erythromycin fluoroquinolone glycylcycline roxithromycin mexc oprj Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_560128chromosome 1Q3YXI543.97%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
YP_559266chromosome 1CAG7407943.77%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_558633chromosome 1YP_00146360243.43%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
YP_559504chromosome 1YP_00145376043.28%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_555933chromosome 3YP_00117612842.69%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_557192chromosome 1AAK8871241.82%catb1%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
YP_558733chromosome 1ZP_0072892141.67%%
YP_554701chromosome 2YP_00143854141.63%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_558607chromosome 1AAS8947141.51%catb3%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
YP_559979chromosome 1CAL4845741.46%dfra26%trimethoprim Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
YP_554814chromosome 2CAB6122941.25%vanra%teicoplanin vancomycin vana vanha vansa vanxa vanya VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_560276chromosome 1YP_00134592241.21%oprm%aminoglycoside beta_lactam fluoroquinolone tetracycline tigecycline mexa mexb mexj mexk mexv mexw mexx mexy Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_553001chromosome 2ZP_0096707441.20%%
YP_558591chromosome 1Q83LR741.05%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_553962chromosome 2YP_00147811340.40%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_555072chromosome 2AAL2744540.38%vanre%vancomycin vane vanse vante vanxye VanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_555955chromosome 3YP_00145376040.35%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_559267chromosome 1BAB3781640.33%mdte%doxorubicin erythromycin mdtf tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
YP_557787chromosome 1NP_78329940.32%qac%qa_compound Small Multidrug Resistance (SMR) protein family. Multidrug resistance efflux pump, which consists of two proteins.
YP_556296chromosome 3AAK8871240.19%catb1%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Below Similarity Cutoff Genes
YP_560631chromosome 1ZP_0015544245.14%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_553098chromosome 2AAP4662242.99%pbp2b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_559056chromosome 1ZP_0015544242.83%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_560505chromosome 1CAD7059242.78%pbp2b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)