ARDB-Antibiotic Resistance Genes Database

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OrganismBacillus anthracis str. 'Ames Ancestor'
Database LinkNCBI Taxon ID: 261594
NCBI Genome Project ID: 10784

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_007530AE0173345227419
plasmid pXO1NC_007322AE017336181677
plasmid pXO2NC_007323AE01733594830


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
YP_020134chromosomeAAK53751100.00%bl2a_1%penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_019683chromosomeZP_00393267100.00%%
YP_019143chromosomeNP_83223390.61%bl2a_iii%penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
YP_016895chromosomeYP_00137362187.76%bcra%bacitracin bcrc ABC transporter system, bacitracin efflux pump.
YP_020753chromosomeABS7348069.57%fosb%fosfomycin Glutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin
YP_017473chromosomeBAA1235565.39%blt%chloramphenicol doxorubicin fluoroquinolone puromycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_018681chromosomeABS7348064.23%fosb%fosfomycin Glutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin
YP_018024chromosomeABF0515962.17%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
YP_019270chromosomeAAC6167160.29%vatc%streptogramin_a Virginiamycin A acetyltransferase, which can inactivate the target drug.
YP_019051chromosomeP2682556.94%cata16%chloramphenicol Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
YP_022048chromosomeAAA8687156.60%vatb%streptogramin_a Virginiamycin A acetyltransferase, which can inactivate the target drug.
YP_021078chromosomeCAA0558855.77%ykkc%na_antimicrobials ykkd Small Multidrug Resistance (SMR) protein family. Multidrug resistance efflux pump, which consists of two proteins.
YP_021754chromosomeAAY5200754.48%vanya%teicoplanin vancomycin vana vanha vanra vansa vanxa VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_021079chromosomeABS7365453.85%ykkd%na_antimicrobials ykkc Small Multidrug Resistance (SMR) protein family. Multidrug resistance efflux pump, which consists of two proteins.
YP_016893chromosomeABF0515952.59%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
YP_016879chromosomeABA7172750.85%vanrg%vancomycin vang vansg vantg vanug vanwg vanxyg vanyg VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_022163chromosomeYP_00117612849.32%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_019199chromosomeABA7172748.94%vanrg%vancomycin vang vansg vantg vanug vanwg vanxyg vanyg VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_020541chromosomeYP_00109629448.56%bcra%bacitracin bcrc ABC transporter system, bacitracin efflux pump.
YP_017433chromosomeYP_00117612848.42%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_018518chromosomeAAL2744548.23%vanre%vancomycin vane vanse vante vanxye VanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_021421chromosomeYP_00137362147.83%bcra%bacitracin bcrc ABC transporter system, bacitracin efflux pump.
YP_017576chromosomeBAA2222847.73%lmrb%lincomycin ABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump.
YP_019693chromosomeQ83LR746.61%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_017665chromosomeBAA2222846.19%lmrb%lincomycin ABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump.
YP_052651chromosomeAAZ9883546.02%vanrd%teicoplanin vancomycin vand vanhd vansd vanxd vanyd VanD type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_018213chromosomeBAA7457245.92%mphb%macrolide Macrolide phosphotransferase
YP_021423chromosomeABK8618845.65%vanra%teicoplanin vancomycin vana vanha vansa vanxa vanya VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_016897chromosomeABK8618844.69%vanra%teicoplanin vancomycin vana vanha vansa vanxa vanya VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_052658chromosomeP4233244.37%bcra%bacitracin bcrc ABC transporter system, bacitracin efflux pump.
YP_020235chromosomeNP_84816744.37%catb2%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
YP_019606chromosomeCAD6019643.68%aac6ie%amikacin dibekacin isepamicin netilmicin sisomicin tobramycin Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
YP_018498chromosomeYP_00157087143.49%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
YP_019121chromosomeQ3Z3Q443.44%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_017739chromosomeAAL2744542.92%vanre%vancomycin vane vanse vante vanxye VanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_022401chromosomeAAY5200242.54%vanra%teicoplanin vancomycin vana vanha vansa vanxa vanya VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_017926chromosomeAAL2744542.04%vanre%vancomycin vane vanse vante vanxye VanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_018606chromosomeABP5733042.03%ant6ia%streptomycin Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
YP_017470chromosomeABS7365341.82%ykkc%na_antimicrobials ykkd Small Multidrug Resistance (SMR) protein family. Multidrug resistance efflux pump, which consists of two proteins.
YP_022171chromosomeAAL2744541.23%vanre%vancomycin vane vanse vante vanxye VanE type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_052625chromosomeZP_0083476341.09%%
YP_021478chromosomeABA7172740.59%vanrg%vancomycin vang vansg vantg vanug vanwg vanxyg vanyg VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_017279chromosomeCAB6122940.53%vanra%teicoplanin vancomycin vana vanha vansa vanxa vanya VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_018120chromosomeABA7172740.52%vanrg%vancomycin vang vansg vantg vanug vanwg vanxyg vanyg VanG type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-serine.
YP_018854chromosomeABK8618840.52%vanra%teicoplanin vancomycin vana vanha vansa vanxa vanya VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_018711chromosomeAAY5200740.28%vanya%teicoplanin vancomycin vana vanha vanra vansa vanxa VanA type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
YP_021733chromosomeQ83LR740.18%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
YP_017998chromosomeP4233240.15%bcra%bacitracin bcrc ABC transporter system, bacitracin efflux pump.
YP_022072chromosomeAAG0898340.11%vgaa%streptogramin_a ABC transporter system, Macrolide-Lincosamide-Streptogramin B efflux pump.
Below Similarity Cutoff Genes
YP_017165chromosomeEDJ9155548.09%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
YP_019170chromosomeAAO4311041.05%lsa80%lincosamide macrolide streptogramin_b ABC efflux family that is resistant to MLS antibiotics