ARDB-Antibiotic Resistance Genes Database

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OrganismSalmonella enterica subsp. enterica serovar Typhi str. CT18
Database LinkNCBI Taxon ID: 220341
NCBI Genome Project ID: 236

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_003198AL5133824809037
plasmid pHCM1NC_003384AL513383218160
plasmid pHCM2NC_003385AL513384106516


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
NP_454702chromosomeCAD01246100.00%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
NP_569416plasmid pHCM1ABS71065100.00%aph6id%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
NP_569370plasmid pHCM1ABG56843100.00%dfra14%trimethoprim Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
NP_569415plasmid pHCM1ABS71064100.00%aph33ib%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
NP_569406plasmid pHCM1CAM91481100.00%cata1%chloramphenicol Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
NP_455431chromosomeCAD0534397.58%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_455072chromosomeCAD0496097.33%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_456105chromosomeCAD0194296.94%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_569411plasmid pHCM1BAF6341895.10%bl2b_tem1%cephalosporin_i cephalosporin_ii penicillin Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
NP_569414plasmid pHCM1CAM9153194.10%sul2%sulfonamide Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
NP_457578chromosomeAB089093.60%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_569429plasmid pHCM1CAO0029292.52%tetb%tetracycline Major facilitator superfamily transporter, tetracycline efflux pump.
NP_457596chromosomeCAD0773092.19%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
NP_455432chromosomeCAD0534491.98%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_455659chromosomeCAD0829089.55%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_458943chromosomeCAD0336389.10%mdtm%acriflavine chloramphenicol norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_455073chromosomeCAD0496187.91%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_455648chromosomeCAD0827881.93%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_458099chromosomeYP_00145166980.00%mdtl%chloramphenicol Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_456842chromosomeAAL2367879.85%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
NP_458139chromosomeCAD0319579.19%emrd%emre Multidrug resistance efflux pump.
NP_455088chromosomeYP_00147737776.09%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_455089chromosomeYP_00147737866.58%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_457015chromosomeNP_75251465.73%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_454977chromosomeYP_00133473057.18%mdtg%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_455878chromosomeCAA3903856.94%aac6if%amikacin dibekacin isepamicin netilmicin sisomicin tobramycin Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
NP_455851chromosomeAAN8081147.17%emre%aminoglycoside emrd Multidrug resistance efflux pump.
NP_456658chromosomeABF2024045.61%catb3%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
NP_455102chromosomeYP_00145376045.27%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_455710chromosomeYP_00157104145.21%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_456247chromosomeAAL5102144.88%aac6ib%amikacin dibekacin isepamicin netilmicin sisomicin tobramycin Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
NP_456514chromosomeYP_00117612841.51%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_458189chromosomeP5270041.06%bl3_l%carbapenem cephalosporin cephamycin penicillin Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
NP_455393chromosomeAAX6827840.36%mdtm%acriflavine chloramphenicol norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Below Similarity Cutoff Genes
NP_454929chromosomeYP_00144437666.00%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
NP_455216chromosomeP7487258.11%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_454806chromosomeP5729653.38%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_458411chromosomeYP_00129003353.15%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_457705chromosomeYP_00129003341.53%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)