ARDB-Antibiotic Resistance Genes Database

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OrganismPseudomonas aeruginosa PAO1
Database LinkNCBI Taxon ID: 208964
NCBI Genome Project ID: 331

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_002516AE0040916264404


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
NP_252799chromosomeAAM08945100.00%bl1_pao%cephalosporin Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
NP_249649chromosomeCAA78448100.00%%
NP_249117chromosomeAAG0381598.47%mexb%aminoglycoside beta_lactam fluoroquinolone tetracycline tigecycline mexa oprm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_249116chromosomeEAZ6096497.13%mexa%aminoglycoside beta_lactam fluoroquinolone tetracycline tigecycline mexb oprm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_252895chromosomeAAG0759396.49%mexh%mexi opmd Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_250708chromosomeAAG0540695.22%mexy%aminoglycoside glycylcycline mexx oprm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_249397chromosomeAAG0409594.34%catb4%chloramphenicol Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
NP_253065chromosomeAAG0776393.22%mexw%mexv oprm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_249118chromosomeBAA2869492.78%oprm%aminoglycoside beta_lactam fluoroquinolone tetracycline tigecycline mexa mexb mexj mexk mexv mexw mexx mexy Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_253288chromosomeAAG0798692.14%mexd%erythromycin fluoroquinolone glycylcycline roxithromycin mexc oprj Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_250709chromosomeAAG0540792.08%mexx%aminoglycoside glycylcycline mexy oprm Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_251184chromosomeAAG0588291.53%mexf%chloramphenicol fluoroquinolone mexe oprn Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_253287chromosomeAAG0798591.02%oprj%erythromycin fluoroquinolone glycylcycline roxithromycin mexc mexd Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_252896chromosomeAAG0759488.82%mexi%mexh opmd Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_251183chromosomeAAG0588186.96%mexe%chloramphenicol fluoroquinolone mexf oprn Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_251185chromosomeAAG0588375.21%oprn%chloramphenicol fluoroquinolone mexe mexf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_252244chromosomeYP_00146360269.08%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
NP_249820chromosomeQ5641556.62%fosa%fosfomycin Glutathione transferase, metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin
NP_254205chromosomeYP_00147737756.29%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_252212chromosomeZP_0163722654.48%%
NP_250549chromosomeAAA7339254.29%aph6ic%streptomycin Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
NP_249283chromosomeYP_00146122353.10%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
NP_252542chromosomeZP_0096522748.78%%
NP_250649chromosomeCAD0773047.04%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
NP_249041chromosomeCAL4845746.67%dfra26%trimethoprim Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
NP_253284chromosomeQ3Z3Q445.66%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_251080chromosomeYP_00157104145.55%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_251450chromosomeYP_79231644.91%%
NP_253289chromosomeYP_85163444.51%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_251195chromosomeZP_0136433342.69%%
NP_250052chromosomeYP_00133566242.63%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_251390chromosomeEAZ6268242.57%%
NP_250231chromosomeAAN8081142.50%emre%aminoglycoside emrd Multidrug resistance efflux pump.
NP_248852chromosomeYP_00134989942.09%%
NP_251728chromosomeYP_00134989941.63%%
NP_248879chromosomeZP_0136433340.53%%
NP_251040chromosomeZP_0072892140.36%%
NP_249922chromosomeYP_41037040.35%mdtn%acriflavine puromycin t_chloride mdto mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_251677chromosomeYP_00145376040.27%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Below Similarity Cutoff Genes
NP_252692chromosomeYP_00145266241.64%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_253732chromosomeYP_00129003340.97%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)