ARDB-Antibiotic Resistance Genes Database

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OrganismShigella flexneri 2a str. 2457T
Database LinkNCBI Taxon ID: 198215
NCBI Genome Project ID: 408

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_004741AE0140734599354


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
NP_835789chromosomeQ83MG8100.00%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
NP_837548chromosomeAAN80811100.00%emre%aminoglycoside emrd Multidrug resistance efflux pump.
NP_837857chromosomeQ83QT899.81%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
NP_839328chromosomeZP_0072643798.82%%
NP_839698chromosomeBAE7815498.14%bl1_ec%cephalosporin Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
NP_838840chromosomeQ83IQ898.09%mdto%acriflavine puromycin t_chloride mdtn mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_838839chromosomeABF0611797.13%mdtp%acriflavine puromycin t_chloride mdtn mdto Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_839191chromosomeQ83PL696.93%mdtl%chloramphenicol Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_838576chromosomeABF0515996.88%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
NP_838556chromosomeABF0514396.83%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_836537chromosomeP6417696.77%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_836133chromosomeNP_83613394.66%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_838053chromosomeABG5683194.10%sul2%sulfonamide Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
NP_836538chromosomeQ83LR793.98%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_837350chromosomeQ7UAH891.03%mdtk%enoxacin norfloxacin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_836134chromosomeNP_70635690.68%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_836774chromosomeQ83LI889.55%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_838841chromosomeQ83P8681.92%mdtn%acriflavine puromycin t_chloride mdto mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_839157chromosomeZP_0092708478.33%%
NP_836149chromosomeYP_00147737775.00%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_838020chromosomeNP_75251464.29%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_836150chromosomeYP_00147737857.82%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_836821chromosomeYP_00145376044.29%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_836165chromosomeYP_00145376042.92%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_837578chromosomeABB5334940.28%vanrb%vancomycin vanb vanhb vansb vanwb vanxb vanyb VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
NP_836495chromosomeZP_0092526940.05%%
Below Similarity Cutoff Genes
NP_836026chromosomeYP_00144437668.00%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
NP_836347chromosomeYP_00145266259.38%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_835880chromosomeP5729653.02%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_839492chromosomeYP_00129003352.51%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)