ARDB-Antibiotic Resistance Genes Database

HOME DOCUMENTATION BLAST ADVANCED  SEARCH BROWSE
     Help

OrganismShigella flexneri 2a str. 301
Database LinkNCBI Taxon ID: 198214
NCBI Genome Project ID: 310

Genome Information:
Replicon NameRefSeqGenBankLength(bp)
chromosomeNC_004337AE0056744607203
plasmid pCP301NC_004851AF386526221618


Resistance Genes:
GeneReplicon SourceBest HitSimilarityTypecutoffResistanceRequireDescription
Above Similarity Cutoff Genes
NP_706007chromosomeQ83MG8100.00%ksga%kasugamycin Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
NP_707822chromosomeAAN80811100.00%emre%aminoglycoside emrd Multidrug resistance efflux pump.
NP_708141chromosomeQ83QT899.81%arna%polymyxin Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
NP_710019chromosomeBAE7815498.14%bl1_ec%cephalosporin Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
NP_709856chromosomeQ83IQ898.09%mdto%acriflavine puromycin t_chloride mdtn mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_709855chromosomeABF0611797.13%mdtp%acriflavine puromycin t_chloride mdtn mdto Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_709488chromosomeQ83PL696.93%mdtl%chloramphenicol Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_708867chromosomeABF0515996.88%baca%bacitracin Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
NP_708846chromosomeABF0514396.83%tolc%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra acrb maca macb mdte mdtf Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_706764chromosomeP6417696.77%maca%macrolide macb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_706355chromosomeNP_70635594.66%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_706765chromosomeQ83LR793.98%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_709341chromosomeABF0599192.36%mdtf%doxorubicin erythromycin mdte tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_709342chromosomeABF0599191.35%mdtf%doxorubicin erythromycin mdte tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_706356chromosomeNP_70635690.68%acra%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acrb tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_706986chromosomeQ83LI889.55%mdth%deoxycholate fosfomycin Major facilitator superfamily transporter. Multidrug resistance efflux pump.
NP_709857chromosomeQ83P8681.92%mdtn%acriflavine puromycin t_chloride mdto mdtp Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_709522chromosomeZP_0092708476.00%%
NP_706371chromosomeYP_00147737775.00%rosb%fosmidomycin rosa Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_708308chromosomeNP_75251464.29%acrb%acriflavin aminoglycoside beta_lactam glycylcycline macrolide acra tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
NP_706372chromosomeYP_00147737857.82%rosa%fosmidomycin rosb Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
NP_707032chromosomeYP_00145376044.29%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_706387chromosomeYP_00145376042.92%macb%macrolide maca tolc Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
NP_707854chromosomeABB5334940.28%vanrb%vancomycin vanb vanhb vansb vanwb vanxb vanyb VanB type vancomycin resistance operon genes, which can synthesize peptidoglycan with modified C-terminal D-Ala-D-Ala to D-alanine--D-lactate.
NP_706721chromosomeZP_0092526940.05%%
Below Similarity Cutoff Genes
NP_706238chromosomeYP_00144437668.00%tet3480%tetracycline Xanthine-guanine phosphoribosyltransferase. Mechanism detail unknown.
NP_706575chromosomeYP_00145266259.38%pbp280%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_706097chromosomeP5729653.02%pbp1b80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
NP_709168chromosomeYP_00129003352.51%pbp1a80%penicillin The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)