ARDB-Antibiotic Resistance Genes Database

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Your Query:     Database: Resistance Gene(ALL)    Genus: Escherichia    

3912 resistance genes are found

Gene IDGene TypeResistance ProfileDescription
NP_757086bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002396537acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAJ13580bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001096393bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI85889macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAD28044bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEJ47676emreaminoglycoside; Multidrug resistance efflux pump.

ABL86709aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ABD59966cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

YP_002894395sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAL77981bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22913dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABJ00256macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABN69112bl1_ampccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEH87838mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAP69693ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_03068343arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

A7ZKH0mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABL76153bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02809713mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDX29262acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI85111mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

B1IV49mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002384138mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAS07428aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

BAE77780mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI43574ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABG21123tetmtetracycline; Ribosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.

YP_002413233bcr

ZP_03046786bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABX74937aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_03070148mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI73810mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03033974mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAG45415bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI77979bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

NP_755678bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03027521bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU54966mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABV19658macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABN48407bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002807373tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR62789emreaminoglycoside; Multidrug resistance efflux pump.

ZP_03086307tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABO20968dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAE00851sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABA86554bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02797541mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04653305cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

ACB17400mdfa

AAZ95178dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAR99057bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAG77311mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACM50317ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABJ03567mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAJ32371bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACQ78102ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EEQ53502mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACR66259bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAC42503tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_002806277mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03047278ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_02805042bcr

EDV63377tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_001457641mdfa

CAA27626ereberythromycin; Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.

CAB96429tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_002891164sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03442698macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU92042acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU93344mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEC26797mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABI20747bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEQ51019bcr

ACO36043bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ43260bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001451542aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03081016arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACH87088tet32tetracycline; Ribosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.

EDS92350acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03060891macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

P02981tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDX41130emrdMultidrug resistance efflux pump.

EDZ89047emrdMultidrug resistance efflux pump.

EDU81298arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDU69629bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ACI29957bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02802166acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAT37598tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACA05168cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

ZP_02794863macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAS09883bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU55724acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04538022acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABY82052bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABM89186bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAG79903mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV16781mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAV01611bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAG79306mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU64822mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03082734mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR00019bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_04651081acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04001961macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

BAA12910mphbmacrolide; Macrolide phosphotransferase

CAR01063mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI75466emrdMultidrug resistance efflux pump.

ABP49578bl1_ampccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002272530bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

CAA71324bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002397219mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACO36040bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABI99919acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI75468emrdMultidrug resistance efflux pump.

EDV85205mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAP22977ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABY82050bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002400591mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66279bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABM89187bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABN54716sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABG69615mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAL29434bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02791753ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACR66236bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAE54322bl2c_pse1carbenicillin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAL02127bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ43239bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU71141bcr

YP_859120mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAQ91440mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

Q8XA14ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_001461939emreaminoglycoside; Multidrug resistance efflux pump.

EDU97170emrdMultidrug resistance efflux pump.

ZP_03002705mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ78813mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03049511mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P32714mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEH84625macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAA28417ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_668451acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002394583bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22922dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABQ16540qnrbfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

CAB89086bl1_foxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACO55744bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAD99253dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002271596bcr

ZP_02785223bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AP_003585tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEH70920mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

B6IBA3mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACO92327ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACI73802mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA45230bcr

ACQ78047bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABN48310bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI32331bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001745309tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG33791sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

NP_943295bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ43242bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

P12056cml_e2chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

B7LQA4mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAS09877bcr

BAE17046bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAZ85967bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAE77580mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAE77108bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAC73966macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_04653299tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_03035619ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

Q8XDZ3arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDU82527mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAQ16669ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDS94006tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03059237mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_04534150mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR63806acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P0AE04ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_002415222mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001693174bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI29964bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002393033tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI87548acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002393502mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002928986mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAV01396mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ61681bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_417970mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03030581bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

CAQ90583mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAE76242acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02806938bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_002411992mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P0AD63bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AP_003607bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAS09879bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB02867mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02797296emrdMultidrug resistance efflux pump.

ZP_03443192bcr

CAR14696bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_02814187aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03251191macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACJ22939dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_02822635tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABC55455dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAR05739mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_753952mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR04659tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Q1R4M4mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEQ49966mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACR66270bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAG76011acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02773088mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABI74448bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI80988arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_540203mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002328440macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDV60909bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

NP_290346mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAZ98825bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_671011tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002410377mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR03024mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACQ78011aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_001464982mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

B7N5M0arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

NP_957551tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_03262822mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABC49789dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

BAB38485mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Q8FL96ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

Q8FIR9mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

Q8X3J5mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABE76830bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AP_001112acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDX39579acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03251395bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

BAD99246dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_02801051emreaminoglycoside; Multidrug resistance efflux pump.

EEQ52549ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

P0A9Z7bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX29315bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAG58876emrdMultidrug resistance efflux pump.

ZP_03068853tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI72003mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV62108macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_851633acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03251713mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG68553acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_286651macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACI71758ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

CAR20717bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_416758arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDS93150mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03035195acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

A7ZZ23mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03027622emrdMultidrug resistance efflux pump.

A1A7A0ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACR64335mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002891089aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ABY81258bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66292bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22930ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDU66536mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU71600mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDX40222tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAJ13564dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAS86426bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABY81263bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03034892bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR02236macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

P67386bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAN83660bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU80771acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABF71540sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAI76927bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR00460mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_065309dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDU75863mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABF29672bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7M0E8ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_03248287acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAV74524bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAA87464ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAA90687dfra14trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002398630arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABV06064mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAB37363bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03059430mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02823259mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03442015macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAR12438mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABE09475mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV05336macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_02805590bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ97964mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI75324mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABC86850bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ05689bl1_ampccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU31563ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_025307mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEH87280bcr

CAA37805cata2chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

ACB20365sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03253729mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_418757mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACM04466bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B1LL36mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABZ89633blebleomycin; Binding protein with a strong affinity to the bleomycin family of antibiotics, which confers resistance to these antibiotics by preventing the bleomycin-induced DNA breakage

EDZ77578mdfa

ACI34695macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABC97701ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_02798954mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI82977mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001743589mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002410189mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV67284mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_752944macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAQ88449arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

B1LEM1mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02803962acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABH07978dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001732854mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ22946ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_001460509mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAT97108bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAN78560ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACI86067mdfa

AAG45720bl2d_oxa10cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03067667mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEJ45642bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDU55682mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03251555mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU72858macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDZ88751emreaminoglycoside; Multidrug resistance efflux pump.

ABY81270bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAV49760ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDU74501ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EEC28960emrdMultidrug resistance efflux pump.

ABY81271bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7MAH6ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_02792731mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAP51280sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_02824882mdfa

ACM50952qnrbfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ABJ01579bcr

EDS91817mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACB04722emrdMultidrug resistance efflux pump.

YP_002402020macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACR66227bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04001478mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03068161bcr

AAG45716bl2_vebcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACO92335dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002332147sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACI81276bcr

AAP43779bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAF65843bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002393699mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAD95493dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EEC30772mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAS11303mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02900823tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_03003683mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02771972mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI76105mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEQ49724cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

YP_001688164aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_04649558mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43237bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABM81537bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX30091mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDX37520emreaminoglycoside; Multidrug resistance efflux pump.

ZP_03067893mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002386557mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

B1LIV8mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAN79487macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACR62062bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAA40158ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACR66295bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU70625bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU72017acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ22950ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAV51338dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03029404macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03263470acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDS91277mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABW06482bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU93782macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDZ80457macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_672169mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

A8A4L2bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EEC26850mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAD11596dfra5trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACI78057tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

B1LIU5mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEQ49854mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAB37816mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAP20926qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

AAQ16668dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAD13465mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACL81499bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66274bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAN83510mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ22932ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDV63400sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_02901868arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAP20908sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABU24282sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAU96789macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAQ86948bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR01062mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAD89187bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ84199bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002414662mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03253488bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

NP_863002ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAO49597ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACR63203macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EEQ53735macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAQ16656aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AAY58236bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU94021bcr

AAL29439bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

Q1RE44macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002295727bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABW05042bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAX18279sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

NP_311101bcr

ABX74938qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ZP_02827017mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03061565acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

B7ND46bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_02786027bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

P14509aph3ibgentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_539901macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03045710macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABY66124bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU35388mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02806919tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU34830tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU89582sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDX41300mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43247bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAM61953bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR01422ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABG46352dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAR15734mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAV91692bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAA67135acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAQ88558macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABV16691bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAY33189aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDU93414mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ63252sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDU91336arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_001458982bcr

AAB20442aac3iiadibekacin; gentamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

CAC20135tetetetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDU94407ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AP_001188emreaminoglycoside; Multidrug resistance efflux pump.

ACL98097ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

Q8X5R8mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_309641emreaminoglycoside; Multidrug resistance efflux pump.

EDU33740mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAR25030aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

CAJ00135bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU54299mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAX54694bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22956dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_424819aph3iiiaamikacin; butirosin; gentamincin_b; isepamicin; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

CAV00708emrdMultidrug resistance efflux pump.

YP_002925252ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EDX31036bcr

AAS13399bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ47205dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDV87976mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAD34475bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAG45721ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABH12146dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABP35557catb3chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

ABI99539ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_002385941acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA24914tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04536663bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

BAD10982ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAS09882bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002384189mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDX30088emrdMultidrug resistance efflux pump.

ABG68552acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAG79483emrdMultidrug resistance efflux pump.

YP_002292212macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAS08423macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAR08391emreaminoglycoside; Multidrug resistance efflux pump.

Q7AFA1mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001481442ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_002386377macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_02804905emrdMultidrug resistance efflux pump.

ABQ52460ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_670193arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002414839emrdMultidrug resistance efflux pump.

ACI73807mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACB17556mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02902679mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAO91855bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001816601dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03256300macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_001687825tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_001816585tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_02785945mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03262464emreaminoglycoside; Multidrug resistance efflux pump.

YP_859277emrdMultidrug resistance efflux pump.

YP_002927964bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

1VIEdfrb1trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001096411sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03085625mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI85055mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR20383emrdMultidrug resistance efflux pump.

ACJ22919dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAV02116mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAA23681dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACN85405aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_03082564tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04649557mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAA97233mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P26838catb2chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

CAR15939mphamacrolide; Macrolide phosphotransferase

ACI85885macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03068885bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAZ85962bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABW77759qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

B7M562mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAA07082bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAA82256ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EEQ51090arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EEQ51723mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAA24057bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV62092macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_190215sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_852164mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACB04754mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_957562bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX29846macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAT48025bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU93795emreaminoglycoside; Multidrug resistance efflux pump.

BAA74572mphbmacrolide; Macrolide phosphotransferase

EDX37020mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ61679bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR18238mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002894486aac3vigentamicin; sisomicin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_03030547mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI86066mdfa

ZP_03260907mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABB89112ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_002328441macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002385298mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02785389acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR06695acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66267bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABP49606bl1_acccephalosporin; e_penicillin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22935dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAQ91624bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAI57695dfra14trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDU98176tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAJ13568ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABG49218aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ABV05258mdfa

NP_416687bcr

BAG28249ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EEJ46130arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABG72267mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02787825ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABC17627aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

YP_002415411sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAQ97782macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_001457307acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACL98096ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_02774519mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAG59522mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDS92446bcr

EEH88803mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACE95680tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_001732500emrdMultidrug resistance efflux pump.

ZP_02786311arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

NP_290713mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03059435mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV60611ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAX53115tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

AAV91762bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03250613mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV83902mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03253559bcr

ABF71543aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EEH87840mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI29961bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU76481acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU92921mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV60973mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04537443mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ87584mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACM90330aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

EDX31749tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI34536mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAK30619bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

P07684ereaerythromycin; Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.

EDX32116mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_976299aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDU85405ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABO37114bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03248759acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ47200ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

BAB64542macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACJ43246bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX31172mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI25607sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDU89622tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_001729821mdfa

ZP_03083336emreaminoglycoside; Multidrug resistance efflux pump.

CAP07795bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABW87621bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI71995bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAA27466aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

CAQ86952tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACJ22925dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EEJ47564mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAV91695bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAN83065mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03442529ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

BAB34866mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAU95778bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001688191sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAR05339mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR05304emrdMultidrug resistance efflux pump.

CAP07777cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

CAR09729bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

NP_308543acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAG76460macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03440896bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABB89109ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_02814138macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_001732345mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI85053mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAG54811acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACQ77656aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDV68869mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_668971mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV82349macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAA04868bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAD28042bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAD99245ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EEH86910emreaminoglycoside; Multidrug resistance efflux pump.

YP_001731920bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_02808796macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAC73565acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03442227mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002386341mdfa

EDU77596emrdMultidrug resistance efflux pump.

CAL30205ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAR13779arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDV89275mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_756458emrdMultidrug resistance efflux pump.

BAG80214tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

AAZ95872bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX41317mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_285748ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAP22974bl2_gescephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_752016ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_03261149bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_851970macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03045275acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAA73392aph6icstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ABO20967ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

B1IRQ9bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ABU48857qnrbfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ACI87541acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV82438mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_542447tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002891173aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_002894390tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDV63874mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002329271mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU87012mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI72899mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002393667emrdMultidrug resistance efflux pump.

ACJ63566sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

NP_311950tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAM70498bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABX75125ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAR17526mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAB41446bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAB40217acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ22943dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002400211mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACR66249bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ90049acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABH07977catb3chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

CAA26199ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDX27688tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

BAD98312cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

BAB38554bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDS90826macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002409907mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAF05613bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03255990acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03058745bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_002296036tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

NP_308083ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EDS91524ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EDU65152mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEC29862acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002408074mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAD57670cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

EDU97542mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR01807acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02778611mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

Q1RBD2mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002391706emreaminoglycoside; Multidrug resistance efflux pump.

EDU56409mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR19648tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02787567emreaminoglycoside; Multidrug resistance efflux pump.

ABY66118bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACO24444dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDZ79798mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P00384dfrb2trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAI57693dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001740012bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03250526mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEQ53236mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03081250mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG46350dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EEH72196mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAO91852bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAT07064bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAO49600aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

AAX56372sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03250262ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

CAR10774mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDS91923mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_671489mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV66781bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

B6I9D0mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002925616emreaminoglycoside; Multidrug resistance efflux pump.

CAR15157mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI30698ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAR94636bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI71754ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

BAC99094bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ90050acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ75623bcr

AAG58191bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ABU52984qnrsfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ZP_03000053ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABL10294aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_002383660acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002388976mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA79767dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDX41091mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_543615mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002393057bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAZ95179ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_03042915mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04537676mdfa

AAL75498ereberythromycin; Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.

EDS93355mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACL98093dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAA38525aac3iiadibekacin; gentamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_03247981mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAD70280bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU66317emrdMultidrug resistance efflux pump.

EDX39645acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACF77147sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03043509arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABU50387bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002412682mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR18528arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03441125mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_859691mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ63572ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAZ67355dfrb1trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDX37168tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

CAQ97952mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ61682bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002386545mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAD38866dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EEH86627mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02827717macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAS11957mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV88000emrdMultidrug resistance efflux pump.

NP_415400macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAG48377bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK59976bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU77073tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABI74447bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAB12022mphbmacrolide; Macrolide phosphotransferase

BAD99250dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001459059arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002295057mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU70809mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAB35795mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABS87589bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK59971bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02793424acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEH84418mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001457720macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABU24286bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK85244bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAC76538mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACO24926sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAR07959mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001746474mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAZ85975bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABF67772aac3vigentamicin; sisomicin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_02814186aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ABJ02995mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV60969mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002414661mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACM04461bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEC30788mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Q8FAX2mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_852989emreaminoglycoside; Multidrug resistance efflux pump.

AAX18269sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAC95170bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04649823mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACF05515aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_002527555mphbmacrolide; Macrolide phosphotransferase

YP_853293bcr

ZP_03031474arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABA29760bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI32075bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABE10084mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002390285acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002926115mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU33723mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI85112mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAP22979sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAT35601bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX38679mdfa

EEH85481bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ACI78060tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AP_000715ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACD02027dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAY43145ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAD28045bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04533957emrdMultidrug resistance efflux pump.

ACG58887bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002291762acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Q0THG4mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_414996acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P22615cata2chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

EEH72576ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_03059493mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AP_004583mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04653306cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

ZP_03048731mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

A1A9W0mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAU97037mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABE05568ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_001461647acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAL48457dfra26trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABG68909macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDX29892macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002891083cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

AAN83032emrdMultidrug resistance efflux pump.

AAW58855bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02797542mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ63281sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABE08916tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04649331mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEH71217mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02778331mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABO20972dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACB20261aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACJ43264bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABW06473bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001744129mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ77591mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA77936emreaminoglycoside; Multidrug resistance efflux pump.

AAK85252bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7NF27mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABP52024dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

B7NAU0mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

1CIAcata3chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

EDU83235mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002394085mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACN56573sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03080423mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV16376sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACJ63280ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDX40254bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

P78218dfra15trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABI20743bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACM48570acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAD99182bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK85248bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAD89606bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAA42562mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACR63260arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDU65737mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04651240mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR05888bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK60186dfra16trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDZ80857mdfa

AAC32891bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEQ51861acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001451543sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_04534149mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03255084ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_03063089tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_002397230mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002401190ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAY33958bl3_vimcarbapenem; cephalosporin; cephamycin; penicillin; Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACO36042bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR01806acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002806354bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ86959aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_04650038bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

CAC85661bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02999353bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

B6I7J8arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

NP_309458mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAA92747sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002928562emrdMultidrug resistance efflux pump.

ACM50313dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABW39613aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

BAD99259dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAQ90469tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEH71849tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR18225mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACP28869tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ABB76658dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002403524arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002396837mdfa

ACR66291bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAG55487qnrbfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ACL98087ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDU97478mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABY81253bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002394431mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEQ53669mdfa

ZP_03249653mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAC53608bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001459829tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001462285mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABQ16541qnrsfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

AAN82252bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAK31370bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03058729tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDS93347emrdMultidrug resistance efflux pump.

ABM89188bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEH84624macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABY82053bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV87706mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03444079mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABE06331mdfa

ABG46351ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACH41160qnrsfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

Q0TJH0macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACI76097mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR62063bcr

A13748aac3iaastromicin; gentamicin; sisomicin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

CAJ13628sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03440322mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV82303macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAP69701ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABY82051bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02823434arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDZ75352acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002415285bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACO36041bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_668452acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAC86407aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AP_004653bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001744454arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDU52425ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

CAA23882tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_002928987mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66285bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66262bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ48210ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_03081408acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

B7M928mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_190212dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

BAD77822dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

4CLAcata3chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

YP_001731124bcr

ACA62821bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002394084mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAB34345mdfa

CAQ89376mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABR28514bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03440565mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI73803mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02782676emreaminoglycoside; Multidrug resistance efflux pump.

YP_852758mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR03613bcr

AAR25033bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAL29435bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

P25744mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001732855mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002527531tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_03050163mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AP_002285mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002390659mdfa

EDZ78153emrdMultidrug resistance efflux pump.

ACJ22936ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_04004686mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU93430bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAC77110bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_539862mdfa

B5YZ89ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAK85250bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAT36680dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABY91281bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22921dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

BAA84973bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV84679arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABN48311bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAS89982bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

Q04515dfra10trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_02798917mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02902384acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03085867macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABH07981cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

BAB12239mphamacrolide; Macrolide phosphotransferase

EEJ46612bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_957533aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDV88873arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACI73808mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV20057mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ86579mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02791209mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAV34201ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDU82043tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ61680bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR03684arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EEC31259macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU97661acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABX47160dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACO24933sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002405458mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04534565mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02771971mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04653148mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03045635mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P06992ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

CAA90683dfra13trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDU63085ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

CAA63057mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAB12602dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAR05738mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_289632bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ABD90508bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU76977bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

Q1RD92mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAC77293mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABG69871emreaminoglycoside; Multidrug resistance efflux pump.

ZP_03441277mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR01130bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV61403emreaminoglycoside; Multidrug resistance efflux pump.

ACR66271bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX31106arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03081249mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002384101bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAL99990bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI47259bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002382086arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAR97950bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ43243bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_756187mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAA35873mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU66773macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACI81280bcr

EDU35630mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACR65508ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_03252051arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_02823034acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA71325bl1_foxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB41777bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002415526mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAR89359bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02822921mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_855309bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03027124mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV08090emrdMultidrug resistance efflux pump.

ABD92777bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI39079mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV87018mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAA52618bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ91404emrdMultidrug resistance efflux pump.

AAP93845bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002389191mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001460473emrdMultidrug resistance efflux pump.

CAQ99174arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002399574bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_001451541aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03048876mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66303bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABQ02277ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAW29470bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI85888macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03059765arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABS72342bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV83263mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR20420mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002384137mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAB18490mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI78059tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU89625aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03030251mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAA37982tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAS07427aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_002414201bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_001744378bcr

NP_417529bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDV68901emrdMultidrug resistance efflux pump.

ACQ78012sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABI20748bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB16814mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABY81257bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABV08485mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002394083mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDX39777mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

B5YXB4mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02812626emreaminoglycoside; Multidrug resistance efflux pump.

EEJ50017mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002405064emrdMultidrug resistance efflux pump.

ACI73805mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU56164mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03029314acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002295058mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR15932sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDV82512mdfa

AAA88337aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

P62577cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

YP_002331222mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABJ00257macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

3CLAcata3chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

YP_002400178emrdMultidrug resistance efflux pump.

EEH87839mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002382998mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABD94117bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AP_004079mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03442211mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU93467mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAX24136bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002396538acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACO92330bl2d_oxa2cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABE09474mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACD03290dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDU92213tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAH60313bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ88901mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAN79805mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABR28513bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAW29412aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ACI76104mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAB16308bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAA92749dfra10trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

BAB34387macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_001729444emreaminoglycoside; Multidrug resistance efflux pump.

EDU51821macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAJ13638bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACN85400dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABP35559dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

P64176macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAO61597bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI23391ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACJ22952ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

B1X8W8arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABA86550bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22951dfra5trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001465157emrdMultidrug resistance efflux pump.

ABB59696dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDU88041mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001731193arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAF72530bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR18399macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002394594aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACJ63276sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDU72857macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002401592acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABE09656emrdMultidrug resistance efflux pump.

CAD11594dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDX31442mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P02980tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDS91386emreaminoglycoside; Multidrug resistance efflux pump.

ACI75467emrdMultidrug resistance efflux pump.

YP_002413307arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

P28246bcr

ACA05169cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

YP_002527542dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03441301acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAK59980bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX31690mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001965403bl2b_tem2cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEH84431mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU76306mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAU99607bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AP_001473mdfa

ZP_03045756macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

B7MAD4bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

Q47066bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU66692mdfa

CAU98306bcr

YP_672168mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABQ16539aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_03048536emreaminoglycoside; Multidrug resistance efflux pump.

NP_310399mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAO33760bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_309470mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV85595mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03035254mdfa

AAT48020bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03045518mdfa

YP_001745783mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

A1A9U9mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

A8A2C2arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

CAA41038bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_756938mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABA86553bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04005559tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

A1A9B7macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABY66378sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAY84705aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

NP_414593ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EDZ88021tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU63604mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001460936bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7M940mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAZ42369bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAU96788macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAZ42370bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAF05611bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR15733mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43238bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABM89222bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002383008mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ63253ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACB18744arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDU77745mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_755652tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_859690mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02798104bcr

EDZ85029acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR13150mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_04537636macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACR66294bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22941dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002389905ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACL81503bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAN80517mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAG57320bcr

ACJ22933dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAQ91708mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAA03776mphamacrolide; Macrolide phosphotransferase

ABO20966dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDV61243mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACO07310bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ83788arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EEH72470mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU93781macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03060937macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_04005585bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

B7LVU5ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAN79059acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAN79792mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABN54713aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_03255564bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR19669bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ACA28712qnrbfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

AAX18278qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

EDV89706bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

BAB72158bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABG49196dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACB02080macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002415417mphamacrolide; Macrolide phosphotransferase

ZP_02904362mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43248bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEQ53090tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA31364sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAF05311bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAU96349acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_539900macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

B1XG62bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

NP_313327mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABF29643bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ77678mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU94364mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAB36566arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002806656ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_02811320acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAS08691mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU81755mdfa

ZP_03035218acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66256bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_788128aph6icstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

P05789ereberythromycin; Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.

YP_001462039mdfa

ZP_03262448macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_02823257mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACM47588bl2_kpccarbapenem; cephalosporin; cephamycin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22931dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_04001960macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACI81277bcr

P0AE06acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAV01397mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_415363mdfa

YP_001729034ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACH53188bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU83460macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_02772884acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03256653emreaminoglycoside; Multidrug resistance efflux pump.

ABN54707bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABY55288ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_03000297mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDX39553emreaminoglycoside; Multidrug resistance efflux pump.

YP_543006mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002925545acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAV91757bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAZ99133bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

Q1R6S4bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

BAD08525ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_02773591mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABI99918acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEC29457bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66243bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03033664macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

BAD08520dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_04534148mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02805508mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03051054mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACB19549macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_001460309mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Q0TJ09mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02814008bcr

AAC73564acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAF74292bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAG54356ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_002411264acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA23886bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ63260sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002404429bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

CAU95938ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_002382193macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_02801981ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_539521acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV65644acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAZ85974bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABY81264bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAA16078arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_02807487emreaminoglycoside; Multidrug resistance efflux pump.

EDV87749mdfa

CAJ13561bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU98497mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEJ46688mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACB03346bcr

ABJ02996mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_418506mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03251333bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7NNT4arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03044758mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAG58910mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ82471mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABG29531bl2b_tem2cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

FAA00067sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACI72002mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEH72197mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAR99059bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABE08940bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ABJ00450mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAY58237bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002293062mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACH73202ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_04533762mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU71217mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEJ46690mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02903696macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABE05991acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV07926mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDX37402ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_02792890arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_02902942ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EEQ51862acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABN69070bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABY66123bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABQ02275ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACQ78010aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03255672mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAD99263dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAZ91703dfra16trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABW06478bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02901439mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACM91559bl2_kpccarbapenem; cephalosporin; cephamycin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7MIJ4mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03044133mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002387144mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABS87588bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAD13871aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AAN81173bcr

CAA73226bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04650756tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ABV82950bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66247bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22947dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001816609bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001463602arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002415399cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

AAZ91706ereaerythromycin; Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.

ACI23388ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAA31362ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACJ43258bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABY66122bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

Q8CVL1mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03044097mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_752945macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAQ97783macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDX31252mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA41328sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAA71915tetetetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDX31482mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ78620mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACO36039bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABN80430bl2_vebcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001816591cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

ZP_03030269mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACB04120tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_290715mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAG77975bcr

CAI57694aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AAG16656cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

YP_668774mdfa

AAN79058acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAN82761mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002295653mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV17682mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ85297macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

Q93LM8bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAC20134tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACI75323mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACQ77683bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ87420tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

A7ZMC9mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAB36497bcr

YP_002273203emrdMultidrug resistance efflux pump.

AAG55799mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001693233blebleomycin; Binding protein with a strong affinity to the bleomycin family of antibiotics, which confers resistance to these antibiotics by preventing the bleomycin-induced DNA breakage

CAR00461mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABK59964sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACR66300bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABV31069bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_669516mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV66046emreaminoglycoside; Multidrug resistance efflux pump.

AAQ95605bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAD99239dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03263009mdfa

ACI85881macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

B1IRC5ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

NP_754683arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

CAQ88517mdfa

ZP_04538023acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02802165acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACK75718bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU78040mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_290956mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02804663mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU34379mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABV18419mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU75945mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV05337macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAY43143dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDU65695mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_543614mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001744116mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAA75610bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU79586macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAY84742bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ79116arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACR63815mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI87544acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002271667arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

CAR02235macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAN86934tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

AAR99493bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAB03644mphamacrolide; Macrolide phosphotransferase

EEJ49077acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03256643acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR09850tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV17510mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAV48840bl3_vimcarbapenem; cephalosporin; cephamycin; penicillin; Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAL77062bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAV00409mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002927225arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABI24166dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABG71588mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABY81265bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAY43829bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR16195ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACR63808acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66230bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66299bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02814137macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EEQ53668mdfa

EDU91530mdfa

EDV85431macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAC33912ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABY55285dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAS08703mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI78056tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_667994ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

BAE78083mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

B1X9T9mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02811321acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002400010mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAF04347dfra5trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAJ13583bl2d_oxa2cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_957555aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

BAD22691dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACF77148sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_001465586mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABM64224ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACB04142bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03251748mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACR66281bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02904358mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001460868mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02811553mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ88634bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAG55811mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAV91761bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAA67773aph3iiiaamikacin; butirosin; gentamincin_b; isepamicin; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AAK95982dfrb2trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAD13464mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ47210dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACN32294tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001409236tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_002400589mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABO10439cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

YP_672170mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43257bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAP69699dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAJ13618sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAA69997mdfa

EDZ83719ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

B7NL69mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

A7ZHE4ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABL10293aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03261148bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAN79400mdfa

YP_851971macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU88191mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAW29415sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03069330mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ77327ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_03248869emreaminoglycoside; Multidrug resistance efflux pump.

ACR56733sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

P62593bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02792085bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

CAC85660bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAF72529bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAQ16660bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU71812mdfa

ZP_02804944mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAD99255dfra5trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

P10738ermblincosamide; macrolide; streptogramin_b; rRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.

ABD59948ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACI72900mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABE08004arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03082269mdfa

AAS09880bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03048739bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02791354mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU65241mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI37342mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAP74085catb3chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

ABX10959qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ABY84715qnrsfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ABI24169ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

Q0TFI7arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDU30636mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAY33959aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

EEH88368ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAT37604catb3chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

ZP_03028414emreaminoglycoside; Multidrug resistance efflux pump.

ABM88811bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_859822bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001460870mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAO49608bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ90532mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU69707ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABL86710ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAV97952bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI38338mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV83128mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002292175mdfa

EDU32308emreaminoglycoside; Multidrug resistance efflux pump.

ABW39610aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACR66307bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU82922emrdMultidrug resistance efflux pump.

BAG76102emreaminoglycoside; Multidrug resistance efflux pump.

AAA97049bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

P0C002sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002331481mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02901431emrdMultidrug resistance efflux pump.

BAE76038ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_001096378aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACJ22940ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABC94951bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK85247bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAC75315arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACQ77725aac3vigentamicin; sisomicin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_02823718emrdMultidrug resistance efflux pump.

EDU79582macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAM22276bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_756186mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03001790mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU71190arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

BAB38486mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEQ53734macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABO20970dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

NP_288831arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03063007sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAO91854bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABV06676arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDU65120bcr

ABN49116bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02774688arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002292211macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAP22736bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ90531mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACF04950dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002404408tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001687824cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

NP_863000sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACR66275bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAL75497ereaerythromycin; Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.

AAG45719cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

CAR07050macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAY85632bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABC17630qnrbfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

P05794dfrb3trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_724481aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03253297mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002386378macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDV64267bcr

EDZ89272arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03034990mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAD24670bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAB33479ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_03029294acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAJ13623sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDV89177mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEQ52221tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDS94089tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_002415223mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABY86753bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABE06672mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAS09881bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI85052mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

B5YXP8arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

CAR10324mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDX31487mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR15801bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001481436tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

CAS07946acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAF63418bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEC29126mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV20158emreaminoglycoside; Multidrug resistance efflux pump.

YP_001688144bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABM81536bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04650350ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

CAQ86961aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_002385942acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR00684mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03255627emreaminoglycoside; Multidrug resistance efflux pump.

YP_794145sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAR26004bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR16348acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAK59978bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEH88804mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG72268mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABC86920bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAU96348acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABH12147ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_002894387cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

ABB97007bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002409457bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_04001999mdfa

ABJ91195bl2_kpccarbapenem; cephalosporin; cephamycin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

FAA00064dfrb2trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACB22021bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02805507mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACE95681tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACI77976bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03081326bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI85054mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_286608mdfa

ACJ43234bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAG58174tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABM89183bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7M0M0mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV82841acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR20609mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU54189bcr

EEQ51762emrdMultidrug resistance efflux pump.

ZP_03067876mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002389552mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABW77758qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

YP_002399550tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AP_004582mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Q0TLT6ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

Q8FCI8mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU76017arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03262189mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAP20910qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ABK78674aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AAZ85963bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B6I3U3mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU56343mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ85377macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAD37412bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03071919sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDX28388ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACI85115mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAZ95176dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACJ63584mphbmacrolide; Macrolide phosphotransferase

BAA15430mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAK85251bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02812071mdfa

EDU87805bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03069403mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002327974acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI85890macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

NP_313090mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02825452emreaminoglycoside; Multidrug resistance efflux pump.

AAK32961bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACH73199ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAK85243bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66248bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ75330tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03059695bcr

YP_891142aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03259094mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI85887macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAA23899cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

AAX18268qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ABV16380aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_002928892aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

B7MA17mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02794862macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABB43029aac3ivapramycin; dibekacin; gentamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_02902278acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV08553bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ99109bcr

AAT46414bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002894492sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

Q8FBV0mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV62173acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAD28043bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002382786bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002331221mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACH53184bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV60776mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03052663macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDV65667acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAV69849dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABG68908macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_04536687tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA43643tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDU70620mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR13705bcr

ABW06474bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03080824mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_863013bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAB30893bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03248265tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002291853emreaminoglycoside; Multidrug resistance efflux pump.

EEH70886emrdMultidrug resistance efflux pump.

ACM04467bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AP_004119emrdMultidrug resistance efflux pump.

YP_002411827macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACI85113mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABF29653bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABC97702ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EDU93150ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABV82974bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABP52023catb3chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

AAN77714bl3_vimcarbapenem; cephalosporin; cephamycin; penicillin; Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002273621mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03003662acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAR06285bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03262528macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03050408mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002390860mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002527539aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ABJ00439mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAS00447cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

EDU77467mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACB02258mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABW06483bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAE77091tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02779574acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

1XPBbl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR05137mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001688163aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDV65915mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAS17730tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_04653070mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

B1LFY7ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_002382152mdfa

ABW39612aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDV84817bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ACI36216ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_001460310mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001729857macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABP35556aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

AAY43150cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

YP_542471bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03261266emreaminoglycoside; Multidrug resistance efflux pump.

Q8X9I3mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDX39781bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_543221mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABI20744bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK60189sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002295887mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI29963bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI23390dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

NP_754605bcr

YP_002269553macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABI20745bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

Q1RDA5mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABW06479bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACM90331aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

1AXBbl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03441486mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P58164mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACF04953sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDU71319emrdMultidrug resistance efflux pump.

ACB20226aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACO92339ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_03069364mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02808672emreaminoglycoside; Multidrug resistance efflux pump.

CAS08341mdfa

YP_001461648acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03261562emrdMultidrug resistance efflux pump.

CAS10898bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAL29436bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI76098mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR10775mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACO24445ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

BAE54325sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

BAC76072bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_669772emreaminoglycoside; Multidrug resistance efflux pump.

BAD83774bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

P77398arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

CAA76796bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ82194bcr

ACM24788aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

CAR11276ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_002388977mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P00383dfrb1trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABS49896catb3chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

BAD98311aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

CAQ97746mdfa

EDZ82123bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_04651279emrdMultidrug resistance efflux pump.

EDV67359mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAP20919aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

AAK59970bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAD22539bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001096419cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

ABY81260bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEC30047mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABZ89574bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR06105mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P32715mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03048614acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI75469emrdMultidrug resistance efflux pump.

AAZ85970bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ75046mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002383661acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI85884macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

BAA35597macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAQ01671bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_859692mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002401983mdfa

EDZ82364mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03027763mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02773008bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV82421mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_752514acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ85858mdfa

ZP_02777696bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

B7LZK7bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

BAF36945bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAR97270bl2_gescephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03256700mdfa

ABX75128dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACJ22957dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDV87664mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002401872emreaminoglycoside; Multidrug resistance efflux pump.

ZP_03081251mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001740011aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACI80987arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAG58655mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43254bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001744329macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAP69685ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAK59977bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI76101mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAA89137bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAL91566bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7NTX0mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABF29640bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX29750mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAA48307aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

2CLAcata3chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

ACC93623sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_02901234mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAT45742bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002405849mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEQ50309emreaminoglycoside; Multidrug resistance efflux pump.

YP_002891124bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7MGD1mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAA25642aac3ivapramycin; dibekacin; gentamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ACB05078mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P37340mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABE10083mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_541535arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACB03415arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002455756sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

NP_286204acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEJ49078acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001732344mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002269511mdfa

AAB51384bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABF67771ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAK31371bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV62125tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ22924ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EEH71218mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABH12142dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_04651080acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02773089mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAB38723mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002331862mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAD99243dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002807856mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABP35560ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_002269112acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_670123bcr

ZP_03048506acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03072008tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_02778572emrdMultidrug resistance efflux pump.

ACR66235bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ78778mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR20126mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV83866mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABK06383bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002928399mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV63413cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

EDU55975tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABY81267bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAS16362cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

CAS11956mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002891158aac3vigentamicin; sisomicin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ABF50980dfra5trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACB18441tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR64647mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAV91752bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAC95176bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAI79493aph3iiiaamikacin; butirosin; gentamincin_b; isepamicin; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACB19530bcr

BAG76652mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03008148macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABU24278dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABA64519cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

AAZ67356ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABB72431bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAU96752mdfa

YP_001096346mphamacrolide; Macrolide phosphotransferase

EEH85010acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03063004ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

P60933bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDV68909mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

1BZAbl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU92658emrdMultidrug resistance efflux pump.

AAG55967emreaminoglycoside; Multidrug resistance efflux pump.

CAC67290bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02777481macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002406102ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

NP_289615tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_418505mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABM89191bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEQ53917mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03032068mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03028090sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_001746548bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03071670emreaminoglycoside; Multidrug resistance efflux pump.

ABV07927mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU53458emreaminoglycoside; Multidrug resistance efflux pump.

EDU82756mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU55803acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43261bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAE78154bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU89776bcr

P27422dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACR65756bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ACM48572tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02822349mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAH60312bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABQ00181bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03070548mdfa

ACO81887aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

EDZ80810emreaminoglycoside; Multidrug resistance efflux pump.

ACJ22929dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03060956mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03086393mdfa

ABC55462dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACK44375aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_190205tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_002807855mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002456172tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

BAC07277ermblincosamide; macrolide; streptogramin_b; rRNA adenine N-6-methyltransferase, which can methylate adenine at position 2058 of 23S rRNA, conferring resistance to erythromycin.

ABK60043ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDU68015emreaminoglycoside; Multidrug resistance efflux pump.

ABY81261bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02775489emreaminoglycoside; Multidrug resistance efflux pump.

AAP20920bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04535214arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

NP_065311ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAT48136mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABG01706ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_001481448sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABG49386bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02806762ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABD93868bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03027135mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAS09947arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

BAD16611bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

A1AFX9bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ACL98091dfra5trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002388518tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAU98030emreaminoglycoside; Multidrug resistance efflux pump.

ACJ43253bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI16551sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAC76093bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_02799454mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEH88255mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02779575acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02776711ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EDS92244acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU78567emreaminoglycoside; Multidrug resistance efflux pump.

ACI03938bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ43235bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03084156emreaminoglycoside; Multidrug resistance efflux pump.

ABV04924acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI71994bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACL98104dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAH10074bl2be_pere_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI86069mdfa

ACQ77731sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABV20933bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

CAR82577bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABQ16538aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_03254895mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAB34388macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACI80986arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_02792066tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAK59973bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_891140sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDU55552mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_852153mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU81346bcr

BAE76647bcr

YP_671031bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_02804662mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAC44147mdfa

ZP_02792813bcr

ACI73804mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABM88809bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR63823mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU33685bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI47257bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04001702emrdMultidrug resistance efflux pump.

AAG57386arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03444341mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAZ91704bl2c_pse1carbenicillin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR07049macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU87282mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ22944ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

BAD99236dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002391447mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACQ77740aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACO36038bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI71756ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_02812172arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABD60314bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV66917mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEQ49855mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002295652mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02803187mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002272514tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ77132mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI82976mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001742172ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACD56150aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_02999783arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABG71130bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

CAS11536emrdMultidrug resistance efflux pump.

B1LLK9arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EEC31090ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EDV60967mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002928597mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ74783mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ63569aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACI85883macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU34084mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001459849bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03048282bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDX38351macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACI01674cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

ACR64682mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04649094mdfa

YP_001740000cata2chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

YP_001096413ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_543005mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P00484cata3chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

YP_002327973acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_753245mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAV28215bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB01590acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_754244emreaminoglycoside; Multidrug resistance efflux pump.

1CLAcata3chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

NP_415399macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU74727mdfa

ZP_03002663mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU73769emreaminoglycoside; Multidrug resistance efflux pump.

AAG45714aac6iaamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

CAA23880tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_03443971arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_04004687mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_290093mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002269911mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV89387acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03080946bcr

CAU99575tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABY81254bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI81278bcr

ZP_03259337ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAB22638bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ84262emreaminoglycoside; Multidrug resistance efflux pump.

ZP_03060697mdfa

ABH07976aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

AAZ85972bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ78256macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002406846mdfa

ZP_03260536tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABE07609emreaminoglycoside; Multidrug resistance efflux pump.

EDU67893macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_04537637macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_02809711mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABA86552bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACQ77653tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACR66225bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEH87990bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAY58238bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK64187bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03257011mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002392016bcr

ZP_02772883acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEH72274bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22958ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABW06484bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002270059emreaminoglycoside; Multidrug resistance efflux pump.

YP_002330819bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03261653mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAQ96758sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABO88211aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

EDX27771ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_002272991mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_863004aac3iaastromicin; gentamicin; sisomicin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

EDU98379mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66242bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002329835bcr

NP_313089mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAN83512mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002894430bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03444625emreaminoglycoside; Multidrug resistance efflux pump.

ZP_02827686emreaminoglycoside; Multidrug resistance efflux pump.

ACH53187bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU89565macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EEJ46689mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002411981mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAB37325bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABY55286dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAA25445dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

BAB38037emrdMultidrug resistance efflux pump.

CAR07011mdfa

AAD13463mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002411265acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03061567acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV62193acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU87996emrdMultidrug resistance efflux pump.

YP_002806550mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02808602mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001742607acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU63329mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABF29639bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66284bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AP_002852arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDX29783mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002269552macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU51695bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

CAJ13630bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDS93114mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAG59278mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66297bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

Q07282tetetetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDU97432arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

NP_756937mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

A1ABK4mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAE16359bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAJ13620bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABJ02569bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03034054bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_853361arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_001745329bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03084924macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU34941arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAV91694bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001465585mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABL09146bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI73809mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACF32746bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI77977bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_02802881macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACJ63560tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDV67278mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAZ85964bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002396873macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDV82079mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_04533992mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU83948mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03050187emrdMultidrug resistance efflux pump.

Q9S169bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU35172bcr

ZP_03003738tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACM04464bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

A7ZW03ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACB04566mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03443956bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ABJ03183mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAQ97338acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02788314mdfa

BAG76424mdfa

1BTLbl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_668960mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU31410acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG71850emrdMultidrug resistance efflux pump.

BAB72156sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAZ14084bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002331449emrdMultidrug resistance efflux pump.

ABD59950sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

BAG78861bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDV64085bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB41759aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

EDV65949bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU35541emrdMultidrug resistance efflux pump.

ACI72897mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACR56731aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

BAB64541macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_04653149mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABX47161dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABX75134dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAY33960dfrb1trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABC69156bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABE06369macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACB02043mdfa

BAD99248dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAP07787dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EEJ47260mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEC30576macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03044893mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_04652709emreaminoglycoside; Multidrug resistance efflux pump.

AAZ85965bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX40954arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_03027677mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_418504mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABH12144dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACC96112bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAY58239bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03069517acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABX75131ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABR28512bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ43265bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_539099ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_04003442emreaminoglycoside; Multidrug resistance efflux pump.

YP_002807394bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_002406254acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAM11671bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACO24447dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACN85406cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

NP_290714mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002527543ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAG59351bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03251088emrdMultidrug resistance efflux pump.

ZP_03069583acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAP69688dfra14trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACI29960bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ63574sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACI29959bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04652002arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ZP_02798314tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02799453mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU34718bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAK59969bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB15698mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AP_004581mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR15345emrdMultidrug resistance efflux pump.

CAR00646emrdMultidrug resistance efflux pump.

ZP_02785204tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU85603emreaminoglycoside; Multidrug resistance efflux pump.

CAS07426sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

BAD97358bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22911dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABM64219dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACR66287bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEJ49641emrdMultidrug resistance efflux pump.

ZP_02780267mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001688187dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002414181tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002383389bcr

ZP_03263421acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACN58169bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_418166mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAJ13577sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002405954tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

EDV63769mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAN59785aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDV67242macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAG55260macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACE95682tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACJ22949dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAR18449bcr

EDU82516ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ZP_04534300bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002401591acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEJ50018mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI87550acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43250bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAB09409mphamacrolide; Macrolide phosphotransferase

EDU74823emreaminoglycoside; Multidrug resistance efflux pump.

YP_002387665bcr

NP_753232mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAJ13625dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAZ95874sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002331930bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAF05612bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR07967qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

BAE77781mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACB17801mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002929226mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EEJ46055bcr

NP_308949mdfa

AAS64385aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_02799536bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001462299mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAC43174mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03003504mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAF01047bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABS58644bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABG72340bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02773630emrdMultidrug resistance efflux pump.

YP_001458725emreaminoglycoside; Multidrug resistance efflux pump.

EDV87651mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAM90335bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_540190mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABN69071bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABW39616tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_02808797macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_543187emrdMultidrug resistance efflux pump.

AAK59974bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03028356arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAY27811bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABV20274mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66250bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABV06599bcr

CAQ89386mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

B1XFX3mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAC76733mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAR05737mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU95663emreaminoglycoside; Multidrug resistance efflux pump.

ZP_03442738tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03086118bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_02779919mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ22927dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAB40216acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03440399emrdMultidrug resistance efflux pump.

YP_001730036mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03083109ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ACO92325ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABO37117sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABV08486mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU66175acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU69673mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001732920bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR06275ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_851935mdfa

B7LM76arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002891180bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_957531sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_02779032bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ACI32877dfra14trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAP74084dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03442688mdfa

AAV91758bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66280bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU66770tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR14676tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_957558aac3iiadibekacin; gentamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ACB12691qnrbfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

AAM89276dfrb3trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAR12449mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABN54714ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAJ77891dfra5trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAR15381mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAG55218mdfa

CAA23656aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03259570mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAV00407mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03252436mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACL98098ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAZ66866bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_418574bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACR66241bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABQ02276bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02805509mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002925546acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDS90134mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_04001737mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABD92776bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACM50321sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

AAR97951bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

Q59408dfra13trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDU97744acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABS12249bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAG47784bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAB38070mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02790926mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02826946ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

B1X9H8mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAA23411acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAG75576ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAW29418sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03250067mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002389621bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAX53116aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

CAR06696acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001465652bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK85246bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU54236arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

EDZ89674mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABB59698ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABK78673aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

CAJ00132bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAR25037tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ABG71110tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACL98085dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_02774768emreaminoglycoside; Multidrug resistance efflux pump.

AAV91753bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV64389mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66301bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001457910mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV61261mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU83161mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAS10878tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI75322mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACC93627dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002270733mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAY46200bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002385549ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABJ03153emrdMultidrug resistance efflux pump.

ZP_02790927mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAX56370ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_03069334bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02791629mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV65597mdfa

BAG80136mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU66715mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDS90130mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03260482bcr

CAR20610mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P32716mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAS11304mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI37321bcr

ABS12043bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAD57667aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_03058351mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002402255mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAQ16671sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACO92329ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_002410375mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABI34705bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI35923emreaminoglycoside; Multidrug resistance efflux pump.

YP_671782mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABQ51091bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAC43180bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001456840ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_002329903arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACI82979mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P00811bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV88957bcr

AAG58654mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ80147acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002294591tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABB72432bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAL36588aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACI29958bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAC86406dfra14trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAT37967cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

AAP43780bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAB34854mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABI20753bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAT37603dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAU98370arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACI72896mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03059573mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU82024bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ABC97703ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EDU87050mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU54975emrdMultidrug resistance efflux pump.

ACJ63274ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

BAE76241acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAV91755bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_290312emrdMultidrug resistance efflux pump.

EEC27901bcr

CAI57691dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_02780016arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

CAA67774cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

AAC43176mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV08718mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02827910mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDV69021arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_001464517bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_001746472mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002398143emreaminoglycoside; Multidrug resistance efflux pump.

YP_002925933macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AAN77713aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ACJ61684bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

NP_415075emreaminoglycoside; Multidrug resistance efflux pump.

CAR20127mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAN82760mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACB01589acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_851634acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU92668mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG49390bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02783802macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002410151emrdMultidrug resistance efflux pump.

AAY43141dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDU32037mdfa

NP_286650macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002455757aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_02903251mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDX37266sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_02827405bcr

BAD99238ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_001732856mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABM89184bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABV19112acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV64400mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABS12248bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAB05887dfra15trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001458447mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02784909mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P00382dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001462076macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACI36997acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAZ85973bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02822350mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABU52985aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ABB97553bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU90921emreaminoglycoside; Multidrug resistance efflux pump.

YP_002332149aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ABG67977bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACQ78109sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002405456mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02806638mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU76372acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAA83545tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACF05513sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAC84572bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU72126acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAA92745ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABY81266bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ88633bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7NR12mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

BAE78330mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ80973macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABK60042dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDZ86822ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_002387727arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACQ77657aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ZP_02902573mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABZ81086bl1_ampccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001096450tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACI05553dfra12trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACJ22948ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAK59979bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001465194mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACB18310mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA07836aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ABK06382bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001740010aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ABY66121bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAA33123sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAS12026bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU65262mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDX38971mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_891141aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_002396872macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03028124ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABV18693acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABM69263bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02814178tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACR66293bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU80874acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002409908mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02823258mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG46354bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002392084arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ABP52026ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAR15732mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001460869mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABP52022aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

EDX39850mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002331863mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR04684bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_02796679mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_04649160macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

AP_001510macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABS70977aac3iiadibekacin; gentamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_02801391mdfa

ACI35274emrdMultidrug resistance efflux pump.

YP_671490mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDV84960tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACB20291bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002273622mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAJ13582aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

ZP_03260119mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ84307mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAE78084mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR05136mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002328705mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002273697bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAD99256ereaerythromycin; Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.

ACB18948macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDU87578acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002891116bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABO10437cml_e3chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

EDV63110emreaminoglycoside; Multidrug resistance efflux pump.

AAV32431bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002411826macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_001745782mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAA23503dfrb2trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAB40740emreaminoglycoside; Multidrug resistance efflux pump.

BAA35598macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAP69698ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACI76100mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AP_004280mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P0AEY9mdfa

AAY33962catb2chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

ABG49388bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDV85291mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAE77620emrdMultidrug resistance efflux pump.

BAB37817mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P37637mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAD95495ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAA16406bcr

CAD30683sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

Q8FH68mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAJ32372bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03062371ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_001746795mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ75605macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

B5YVT5mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02901165bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABW39611aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDV83115emrdMultidrug resistance efflux pump.

EDX38985mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACA97846bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAX58682bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR10353emrdMultidrug resistance efflux pump.

ZP_02784602mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABE07927bcr

ACJ43252bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EEJ47247mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_957554bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB16023acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAG79307mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03003285emrdMultidrug resistance efflux pump.

ABM89190bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02802335emreaminoglycoside; Multidrug resistance efflux pump.

Q8X4L0mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_752515acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAZ85968bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABN69105bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ43249bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

P0AE07acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACF17982sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACB17069mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABE05990acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAC73965macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAA64682bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002891090aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

EDZ87055mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABI24168ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAJ13634bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB17398mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P69368mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABF67777sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

YP_002272990mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEQ53310bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABC73077bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU89632macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002330799tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ78460bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

ZP_03067706emrdMultidrug resistance efflux pump.

ZP_03048355tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACN39712bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAL29437bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02780347bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02796020emreaminoglycoside; Multidrug resistance efflux pump.

EEQ53237mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_312674mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDZ84980acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABS58645bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22923dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_002925897mdfa

YP_001732532mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

A8A0L0mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABV04923acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAG45723sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_03029420macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002390695macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03086301acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03255422emrdMultidrug resistance efflux pump.

ABJ16468bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU84928mdfa

CAQ98572mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ63571dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACJ22917dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ABE09690mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02823757mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU69581tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAR87481sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDU87023mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAG79901mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ43256bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU55678mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAG79976bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02797257mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002408235macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

B1IXT2arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_002384075tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAC74149mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ63256cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

YP_002409438tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002394596aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

CAL30208sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABV06342emreaminoglycoside; Multidrug resistance efflux pump.

Q0TAZ8mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAP20905dfra16trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDV80791ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAQ16666bl3_vimcarbapenem; cephalosporin; cephamycin; penicillin; Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABG71589mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI76103mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG49185mphamacrolide; Macrolide phosphotransferase

ZP_02791170emrdMultidrug resistance efflux pump.

ABJ01044mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_417507tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_418129emrdMultidrug resistance efflux pump.

EDS93081bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001464496tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV21017mdfa

ACD87553ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

AAR25032bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B7M5T7arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

NP_415583mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002396141ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

YP_002385033mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAB18489mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI77980bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDU65837bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAP51285ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACB05142bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK17194bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02900713bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDS93979bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

AAY43147cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

ABG46355bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002527540aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

ACI80990arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAZ85969bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI01678sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

B7NJS0bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_001096354sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDU68097mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_04003724mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_001729368acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABG72269mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ22915dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACA30422bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACA09610bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_190213catb3chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

ACQ78006tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

YP_001746039mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABW77757qnrsfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

ABJ01275emreaminoglycoside; Multidrug resistance efflux pump.

ABE06370macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABJ16466sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_04649095mdfa

ZP_03072121mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABY81268bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAA27446aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AAG54812acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_313091mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABO20965dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001461223ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EEJ49374macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002929056bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_04004395mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAB47941mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI87547acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAP07771tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

AAC33914sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACI96034sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ABG69070mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAW29416cata2chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

ZP_02803963acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03002120mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ80800acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001740033tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ACI39747mdfa

ACI87543acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03253854mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_002405100mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ43244bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI39579emreaminoglycoside; Multidrug resistance efflux pump.

ZP_03071770ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

ABV08126mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABV18113mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002403464bcr

ACI25375bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDZ88392mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002268661ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

NP_312420mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACR66298bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03030551mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAD38867ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ABY81273bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002382533mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

CAU97026mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI85051mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_02792360mdfa

AP_001509macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAV01394mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABU53682bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

A7ZRT8bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

NP_287355emreaminoglycoside; Multidrug resistance efflux pump.

YP_001409239bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ22937dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03034063tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P02982tetatetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ZP_02775049mdfa

CAA27740dfrb3trimethoprim; Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03045286acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

P23895emreaminoglycoside; Multidrug resistance efflux pump.

EDU71373mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI05556dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

EDV66790tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_859119mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI71993bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001731898tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABM64223cml_e1chloramphenicol; Major facilitator superfamily transporter, chloramphenicol efflux pump.

AAP20913sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EEQ53070bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDX38362macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACR63809mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002806276mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

B7MIK6mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

P60932bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_002407398mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03081407acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

A8A6H2mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACB41778bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACO24928bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABH07979ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAB41448ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAQ89159bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001463535bcr

EDU97183mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ63568aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

YP_671751emrdMultidrug resistance efflux pump.

YP_002295234emrdMultidrug resistance efflux pump.

ZP_02901634bcr

ABX75130bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_001816598sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACL98100ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_002385214bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAK85249bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABC49787dfra16trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACF77145sul2sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

CAR16958mdfa

CAS07945acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_312641emrdMultidrug resistance efflux pump.

ABJ02548tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI85886macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_02810384mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

B6I428bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDU67882macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAR16059mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

EDU75852mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACJ47203ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

EDU91968acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02781491emreaminoglycoside; Multidrug resistance efflux pump.

ACI38652mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Q1R9G0arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

YP_539522acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03032060emrdMultidrug resistance efflux pump.

BAB38487mdtnacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02791355mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU81738mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABK06381bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI71755ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

EEH85505tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAW31096qnrafluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.

YP_668809macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_02772183mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03251814emreaminoglycoside; Multidrug resistance efflux pump.

AAZ95870sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACR63814emrdMultidrug resistance efflux pump.

P75831macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ZP_03003143acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAP69684dfra1trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

AAC75243bcr

CAR02197mdfa

ABI20746bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACB01666emreaminoglycoside; Multidrug resistance efflux pump.

ZP_03033688macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABA86551bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACJ63257ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ZP_02785596mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

NP_756936mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR15158mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDZ83530mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV20565mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU86754arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

ACF04955bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACI85882macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ACD87556sul3sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

EDU54110emreaminoglycoside; Multidrug resistance efflux pump.

ACB17952mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03080836mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABS58643bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03043095bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EEQ49725cata1chloramphenicol; Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.

ABH07980ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

YP_001729858macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

ABV07446tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV53913aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

AAD50825dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

CAF31623dfra22trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

YP_001744328macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

CAV01873tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

ABY81269bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAD38868dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

BAD08522dfra7trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ZP_03253539tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABA62022bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002410481bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAR01061mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI81279bcr

ACR19212tetbtetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

AAC76539mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAX18263bl2d_oxa1cloxacillin; penicillin; Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

B5Z497mdtkenoxacin; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

YP_002292391mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

AAX18276sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ACR66278bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_02781644mdfa

EDV89495acraacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

NP_863005aac6ibamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

EDV69193bcr

ZP_02809712mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAR01296mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACJ22908dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

NP_957565bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03031646bcr

ACI75325mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABP35554dfra17trimethoprim; Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.

ACR64705mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001464983mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

BAE17045bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ZP_03081715mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABF67765tetctetracycline; Major facilitator superfamily transporter, tetracycline efflux pump.

CAJ13633sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

ZP_02796567emreaminoglycoside; Multidrug resistance efflux pump.

ABZ04072catb3chloramphenicol; Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.

ACJ43241bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAG45717ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

BAD99252ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

BAG78840tolcacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ABV07466bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

YP_002408358arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAV91759bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ89773bcr

AAR98572bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABG33800aph3iagentamincin_b; kanamycin; lividomycin; neomycin; paromomycin; ribostamycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

CAD08929bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAG45713ant2iadibekacin; gentamicin; kanamycin; sisomicin; tobramycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACB16010bacabacitracin; Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.

EDU62815arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

AAK59975bl1_moxcephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAA35851mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACI85114mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ZP_03033976mdtgdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACB05077mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

YP_001746002emrdMultidrug resistance efflux pump.

ABG68873mdfa

AAS01377bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

BAB72153aac6iaamikacin; dibekacin; isepamicin; netilmicin; sisomicin; tobramycin; Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.

AAT97112bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU97946mdtmacriflavine; chloramphenicol; norfloxacin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACK44376aph6idstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AAD37413bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDU96156mdfa

AAY58235bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACM04456bl2be_shv2e_cephalosporin; monobactam; n_cephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAM18924bl2b_temcephalosporin; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AAO49595sul1sulfonamide; Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.

Q8XED0macbmacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

YP_002292403mdthdeoxycholate; fosfomycin; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ABC94952bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002393501mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Q8X5R9mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_02903427mdfa

AAO38248ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

CAQ87648ksgakasugamycin; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.

AAN83511mdtoacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ACI37839arnapolymyxin; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

CAR94645bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

YP_002332148aph33ibstreptomycin; Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

AAV28216bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAQ91710mdtpacriflavine; puromycin; t_chloride; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

ZP_03049544mdtfdoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDU83462macamacrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.

EDV88641mdtedoxorubicin; erythromycin; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

CAS11569mdtlchloramphenicol; Major facilitator superfamily transporter. Multidrug resistance efflux pump.

ACR66296bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ABJ03698bl1_eccephalosporin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

EDX29260acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EDS90977mdfa

ABY81262bl2b_tem1cephalosporin_i; cephalosporin_ii; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

AP_001111acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

EEH85011acrbacriflavin; aminoglycoside; beta_lactam; glycylcycline; macrolide; Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

AAX35760bl1_cmy2carbapenem; cefoxitin; ceftazidime; ceftriaxone; cephalosporin; cephamycin; Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

ACO36037bl2be_ctxmceftazidime; cephalosporin_i; cephalosporin_ii; cephalosporin_iii; monobactam; penicillin; Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.

CAA68436ant3iaspectinomycin; streptomycin; Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ACO72576qnrbfluoroquinolone; Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.