ARDB-Antibiotic Resistance Genes Database

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GenusShigella
Resistance TypeType: aac6ia
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: amikacin  dibekacin  isepamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: aac6ib
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: amikacin  dibekacin  isepamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: acra
Require: acrb    tolc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
Resistance TypeType: acrb
Require: tolc    acra    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
Resistance TypeType: ant2ia
Description: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Resistance: dibekacin  gentamicin  kanamycin  sisomicin  tobramycin  
Resistance TypeType: ant3ia
Description: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Resistance: spectinomycin  streptomycin  
Resistance TypeType: aph33ib
Description: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Resistance: streptomycin  
Resistance TypeType: aph3ia
Description: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Resistance: gentamincin_b  kanamycin  lividomycin  neomycin  paromomycin  ribostamycin  
Resistance TypeType: aph6id
Description: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Resistance: streptomycin  
Resistance TypeType: arna
Description: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Resistance: polymyxin  
Resistance TypeType: baca
Description: Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
Resistance: bacitracin  
Resistance TypeType: bcr
Resistance:
Resistance TypeType: bl1_ec
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  
Resistance TypeType: bl2be_ctxm
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: ceftazidime  cephalosporin_i  cephalosporin_ii  cephalosporin_iii  monobactam  penicillin  
Resistance TypeType: bl2be_shv2
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: e_cephalosporin  monobactam  n_cephalosporin  penicillin  
Resistance TypeType: bl2b_tem
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2b_tem1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin_i  cephalosporin_ii  penicillin  
Resistance TypeType: bl2d_oxa1
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa10
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl3_imp
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: cata1
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata3
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: catb3
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol  
Resistance TypeType: dfra1
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra12
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra17
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra7
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: emrd
Require: emre    
Description: Multidrug resistance efflux pump.
Resistance:
Resistance TypeType: emre
Require: emrd    
Description: Multidrug resistance efflux pump.
Resistance: aminoglycoside  
Resistance TypeType: ksga
Description: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
Resistance: kasugamycin  
Resistance TypeType: maca
Require: tolc    macb    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Resistance: macrolide  
Resistance TypeType: macb
Require: maca    tolc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Resistance: macrolide  
Resistance TypeType: mdfa
Resistance:
Resistance TypeType: mdte
Require: mdtf    tolc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: doxorubicin  erythromycin  
Resistance TypeType: mdtf
Require: tolc    mdte    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: doxorubicin  erythromycin  
Resistance TypeType: mdtg
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: deoxycholate  fosfomycin  
Resistance TypeType: mdth
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: deoxycholate  fosfomycin  
Resistance TypeType: mdtk
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: enoxacin  norfloxacin  
Resistance TypeType: mdtl
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: mdtm
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: acriflavine  chloramphenicol  norfloxacin  
Resistance TypeType: mdtn
Require: mdto    mdtp    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavine  puromycin  t_chloride  
Resistance TypeType: mdto
Require: mdtn    mdtp    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavine  puromycin  t_chloride  
Resistance TypeType: mdtp
Require: mdtn    mdto    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavine  puromycin  t_chloride  
Resistance TypeType: mpha
Description: Macrolide phosphotransferase
Resistance: macrolide  
Resistance TypeType: qnra
Description: Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
Resistance: fluoroquinolone  
Resistance TypeType: qnrb
Description: Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
Resistance: fluoroquinolone  
Resistance TypeType: qnrs
Description: Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
Resistance: fluoroquinolone  
Resistance TypeType: rosa
Require: rosb    
Description: Efflux pump/potassium antiporter system. RosA: Major facilitator superfamily transporter. RosB: Potassium antiporter.
Resistance: fosmidomycin  
Resistance TypeType: sul1
Description: Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
Resistance: sulfonamide  
Resistance TypeType: sul2
Description: Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
Resistance: sulfonamide  
Resistance TypeType: teta
Description: Major facilitator superfamily transporter, tetracycline efflux pump.
Resistance: tetracycline  
Resistance TypeType: tetb
Description: Major facilitator superfamily transporter, tetracycline efflux pump.
Resistance: tetracycline  
Resistance TypeType: tetd
Description: Major facilitator superfamily transporter, tetracycline efflux pump.
Resistance: tetracycline  
Resistance TypeType: tolc
Require: acrb    mdtf    maca    macb    acra    mdte    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
SpeciesShigella boydii CDC 3083-94     Shigella boydii Sb227     Shigella dysenteriae     Shigella dysenteriae 1012     Shigella dysenteriae Sd197     Shigella flexneri     Shigella flexneri 2a     Shigella flexneri 2a str. 2457T     Shigella flexneri 2a str. 301     Shigella flexneri 5     Shigella flexneri 5 str. 8401     Shigella sonnei     Shigella sonnei Ss046     Shigella sp. ER.1.23     Shigella sp. SHV-71    
Database LinkNCBI Taxon ID: 620