ARDB-Antibiotic Resistance Genes Database

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GenusKlebsiella
Resistance TypeType: aac3ia
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: astromicin  gentamicin  sisomicin  
Resistance TypeType: aac3iia
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: dibekacin  gentamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: aac6ia
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: amikacin  dibekacin  isepamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: aac6ib
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: amikacin  dibekacin  isepamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: aac6iia
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: dibekacin  gentamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: acra
Require: acrb    tolc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
Resistance TypeType: acrb
Require: tolc    acra    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
Resistance TypeType: ant2ia
Description: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Resistance: dibekacin  gentamicin  kanamycin  sisomicin  tobramycin  
Resistance TypeType: ant3ia
Description: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Resistance: spectinomycin  streptomycin  
Resistance TypeType: aph33ib
Description: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Resistance: streptomycin  
Resistance TypeType: aph3ia
Description: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Resistance: gentamincin_b  kanamycin  lividomycin  neomycin  paromomycin  ribostamycin  
Resistance TypeType: aph6ic
Description: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Resistance: streptomycin  
Resistance TypeType: aph6id
Description: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Resistance: streptomycin  
Resistance TypeType: baca
Description: Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
Resistance: bacitracin  
Resistance TypeType: bcr
Resistance:
Resistance TypeType: bl1_acc
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  e_penicillin  
Resistance TypeType: bl1_ampc
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  
Resistance TypeType: bl1_cmy2
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cefoxitin  ceftazidime  ceftriaxone  cephalosporin  cephamycin  
Resistance TypeType: bl1_fox
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  
Resistance TypeType: bl1_mox
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  
Resistance TypeType: bl2a_okp
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2be_ctxm
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: ceftazidime  cephalosporin_i  cephalosporin_ii  cephalosporin_iii  monobactam  penicillin  
Resistance TypeType: bl2be_oxy1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: monobactam  penicillin  
Resistance TypeType: bl2be_shv2
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: e_cephalosporin  monobactam  n_cephalosporin  penicillin  
Resistance TypeType: bl2b_tem
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2b_tem1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin_i  cephalosporin_ii  penicillin  
Resistance TypeType: bl2c_pse1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbenicillin  penicillin  
Resistance TypeType: bl2d_oxa1
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa10
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa2
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa9
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2_ges
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2_kpc
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl2_len
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl3_imp
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_vim
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: cata1
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata2
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata3
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: catb2
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol  
Resistance TypeType: catb3
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol  
Resistance TypeType: cml_e1
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e3
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: dfra1
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra10
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra12
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra14
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra15
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra17
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra19
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra21
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra22
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra5
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra7
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfrb1
Description: Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfrb3
Description: Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: emrd
Require: emre    
Description: Multidrug resistance efflux pump.
Resistance:
Resistance TypeType: erea
Description: Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.
Resistance: erythromycin  
Resistance TypeType: ksga
Description: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
Resistance: kasugamycin  
Resistance TypeType: maca
Require: tolc    macb    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Resistance: macrolide  
Resistance TypeType: macb
Require: maca    tolc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Resistance: macrolide  
Resistance TypeType: mdfa
Resistance:
Resistance TypeType: mdtg
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: deoxycholate  fosfomycin  
Resistance TypeType: mdth
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: deoxycholate  fosfomycin  
Resistance TypeType: mdtk
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: enoxacin  norfloxacin  
Resistance TypeType: qnra
Description: Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
Resistance: fluoroquinolone  
Resistance TypeType: qnrb
Description: Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
Resistance: fluoroquinolone  
Resistance TypeType: qnrs
Description: Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
Resistance: fluoroquinolone  
Resistance TypeType: sul1
Description: Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
Resistance: sulfonamide  
Resistance TypeType: sul2
Description: Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
Resistance: sulfonamide  
Resistance TypeType: teta
Description: Major facilitator superfamily transporter, tetracycline efflux pump.
Resistance: tetracycline  
Resistance TypeType: tetd
Description: Major facilitator superfamily transporter, tetracycline efflux pump.
Resistance: tetracycline  
Resistance TypeType: tete
Description: Major facilitator superfamily transporter, tetracycline efflux pump.
Resistance: tetracycline  
Resistance TypeType: tetm
Description: Ribosomal protection protein, which protects ribosome from the translation inhibition of tetracycline.
Resistance: tetracycline  
Resistance TypeType: tolc
Require: acrb    mdtf    maca    macb    acra    mdte    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
SpeciesKlebsiella aerogenes     Klebsiella oxytoca     Klebsiella pneumoniae     Klebsiella pneumoniae 342     Klebsiella pneumoniae NTUH-K2044     Klebsiella pneumoniae subsp. ozaenae     Klebsiella sp.     Klebsiella sp. 25     Klebsiella sp. 49     Klebsiella sp. 52     Klebsiella sp. ARS06-441    
Database LinkNCBI Taxon ID: 570