ARDB-Antibiotic Resistance Genes Database

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GenusCitrobacter
Resistance TypeType: aac3iia
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: dibekacin  gentamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: aac6ia
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: amikacin  dibekacin  isepamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: aac6ib
Description: Aminoglycoside N-acetyltransferase, which modifies aminoglycosides by acetylation.
Resistance: amikacin  dibekacin  isepamicin  netilmicin  sisomicin  tobramycin  
Resistance TypeType: acra
Require: acrb    tolc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
Resistance TypeType: acrb
Require: tolc    acra    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
Resistance TypeType: ant2ia
Description: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Resistance: dibekacin  gentamicin  kanamycin  sisomicin  tobramycin  
Resistance TypeType: ant3ia
Description: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.
Resistance: spectinomycin  streptomycin  
Resistance TypeType: aph3ia
Description: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.
Resistance: gentamincin_b  kanamycin  lividomycin  neomycin  paromomycin  ribostamycin  
Resistance TypeType: arna
Description: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Resistance: polymyxin  
Resistance TypeType: baca
Description: Undecaprenyl pyrophosphate phosphatase, which consists in the sequestration of Undecaprenyl pyrophosphate.
Resistance: bacitracin  
Resistance TypeType: bcr
Resistance:
Resistance TypeType: bl1_ampc
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  
Resistance TypeType: bl1_cmy2
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cefoxitin  ceftazidime  ceftriaxone  cephalosporin  cephamycin  
Resistance TypeType: bl1_mox
Description: Class C beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  
Resistance TypeType: bl2be_ctxm
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: ceftazidime  cephalosporin_i  cephalosporin_ii  cephalosporin_iii  monobactam  penicillin  
Resistance TypeType: bl2be_per
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: e_cephalosporin  monobactam  n_cephalosporin  penicillin  
Resistance TypeType: bl2be_shv2
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: e_cephalosporin  monobactam  n_cephalosporin  penicillin  
Resistance TypeType: bl2b_tem
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2b_tem1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin_i  cephalosporin_ii  penicillin  
Resistance TypeType: bl2b_ula
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2d_oxa1
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa10
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2_kpc
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_cit
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_imp
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: dfra1
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra12
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra16
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra25
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: emrd
Require: emre    
Description: Multidrug resistance efflux pump.
Resistance:
Resistance TypeType: ksga
Description: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance.
Resistance: kasugamycin  
Resistance TypeType: maca
Require: tolc    macb    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Resistance: macrolide  
Resistance TypeType: macb
Require: maca    tolc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump. Macrolide-specific efflux system.
Resistance: macrolide  
Resistance TypeType: mdfa
Resistance:
Resistance TypeType: mdtf
Require: tolc    mdte    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: doxorubicin  erythromycin  
Resistance TypeType: mdtg
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: deoxycholate  fosfomycin  
Resistance TypeType: mdth
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: deoxycholate  fosfomycin  
Resistance TypeType: mdtk
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: enoxacin  norfloxacin  
Resistance TypeType: mdtl
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: mdtm
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: acriflavine  chloramphenicol  norfloxacin  
Resistance TypeType: pbp2
Description: The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Resistance: penicillin  
Resistance TypeType: qnra
Description: Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
Resistance: fluoroquinolone  
Resistance TypeType: qnrb
Description: Pentapeptide repeat family, which protects DNA gyrase from the inhibition of quinolones.
Resistance: fluoroquinolone  
Resistance TypeType: sul1
Description: Sulfonamide-resistant dihydropteroate synthase, which can not be inhibited by sulfonamide.
Resistance: sulfonamide  
Resistance TypeType: tetc
Description: Major facilitator superfamily transporter, tetracycline efflux pump.
Resistance: tetracycline  
Resistance TypeType: tetd
Description: Major facilitator superfamily transporter, tetracycline efflux pump.
Resistance: tetracycline  
Resistance TypeType: tolc
Require: acrb    mdtf    maca    macb    acra    mdte    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: acriflavin  aminoglycoside  beta_lactam  glycylcycline  macrolide  
SpeciesCitrobacter amalonaticus     Citrobacter braakii     Citrobacter freundii     Citrobacter koseri     Citrobacter murliniae     Citrobacter sedlakii     Citrobacter sp. 30_2     Citrobacter sp. CI157     Citrobacter sp. CI174     Citrobacter sp. CI888     Citrobacter sp. CI920     Citrobacter sp. CI925     Citrobacter sp. TA3     Citrobacter sp. TA6     Citrobacter werkmanii     Citrobacter youngae     Citrobacter youngae ATCC 29220    
Database LinkNCBI Taxon ID: 544