ARDB-Antibiotic Resistance Genes Database

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Antibioticerythromycin
DescriptionA bacteriostatic antibiotic substance produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Action Target23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor
SynonymsEM   Akne-mycin   Staticin   Pce   Eryc   Erygel   T-stat
Resistance TypeType: erea
Description: Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.
Resistance: erythromycin  
Resistance TypeType: ereb
Description: Erythromycin esterase, which can inactivate erythromycin by lactone ring cleavage.
Resistance: erythromycin  
Resistance TypeType: mdte
Require: mdtf    tolc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: doxorubicin  erythromycin  
Resistance TypeType: mdtf
Require: tolc    mdte    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: doxorubicin  erythromycin  
Resistance TypeType: mexc
Require: oprj    mexd    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: erythromycin  fluoroquinolone  glycylcycline  roxithromycin  
Resistance TypeType: mexd
Require: oprj    mexc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: erythromycin  fluoroquinolone  glycylcycline  roxithromycin  
Resistance TypeType: oprj
Require: mexd    mexc    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: erythromycin  fluoroquinolone  glycylcycline  roxithromycin  
Database LinksKEGG DRUG: D00140
ChEBI ID: CHEBI: 23953