ARDB-Antibiotic Resistance Genes Database

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Antibioticactinomycin
DescriptionAn antitumor antibiotic derived from Streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
Action TargetRNA polymerase inhibitor
SynonymsDactinomycin   Cosmegen
Database LinksKEGG DRUG: D00214
ChEBI ID: CHEBI: 15369