ARDB-Antibiotic Resistance Genes Database

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Antibioticchloramphenicol
DescriptionAn antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Action Target23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor
SynonymsCP   Chloromycetin   Econochlor   Amphicol
Resistance TypeType: adeb
Require: adec    adea    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: aminoglycoside  chloramphenicol  
Resistance TypeType: adec
Require: adeb    adea    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: aminoglycoside  chloramphenicol  
Resistance TypeType: blt
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: chloramphenicol  doxorubicin  fluoroquinolone  puromycin  
Resistance TypeType: bmr
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: chloramphenicol  fluoroquinolone  
Resistance TypeType: cata1
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata10
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata11
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata12
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata13
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata14
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata15
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata16
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata2
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata3
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata4
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata5
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata6
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata7
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata8
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: cata9
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol  
Resistance TypeType: catb1
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol  
Resistance TypeType: catb2
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol  
Resistance TypeType: catb3
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol  
Resistance TypeType: catb4
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol  
Resistance TypeType: catb5
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol  
Resistance TypeType: ceoa
Require: ceob    opcm    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: ceob
Require: opcm    ceoa    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e1
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e2
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e3
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e4
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e5
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e6
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e7
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: cml_e8
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: mdtl
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: mdtm
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: acriflavine  chloramphenicol  norfloxacin  
Resistance TypeType: mexe
Require: mexf    oprn    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol  fluoroquinolone  
Resistance TypeType: mexf
Require: mexe    oprn    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol  fluoroquinolone  
Resistance TypeType: opcm
Require: ceob    ceoa    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol  
Resistance TypeType: oprn
Require: mexf    mexe    
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol  fluoroquinolone  
Database LinksKEGG DRUG: D00104
ChEBI ID: CHEBI: 17698