ARDB-Antibiotic Resistance Genes Database

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Antibiotictrimethoprim
DescriptionA pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
Resistance TypeType: dfra1
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra10
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra12
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra13
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra14
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra15
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra16
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra17
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra19
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra20
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra21
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra22
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra23
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra24
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra25
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra26
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra5
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfra7
Description: Group A drug-insensitive dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfrb1
Description: Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfrb2
Description: Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfrb3
Description: Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Resistance TypeType: dfrb6
Description: Group B drug-insensitive R67 dihydrofolate reductase, which can not be inhibited by trimethoprim.
Resistance: trimethoprim  
Database LinksKEGG DRUG: D06236
ChEBI ID: CHEBI: 45924