ARDB-Antibiotic Resistance Genes Database

HOME DOCUMENTATION BLAST ADVANCED  SEARCH BROWSE
     Help

Antibioticrifampin
DescriptionA semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
Action Target23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor
SynonymsRifadin   Rifampin   Rimactane
Resistance TypeType: rif
Resistance: rifampin  
Database LinksKEGG DRUG: D00211