ARDB-Antibiotic Resistance Genes Database

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Antibioticpenicillin
DescriptionA group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Action Targetpenicillin binding protein (PBP), cell wall synthesis inhibitor
Resistance TypeType: bl2_ges
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2_kpc
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl2_len
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2_veb
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2a_1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2a_exo
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2a_iii
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2a_iii2
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2a_kcc
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2a_nps
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2a_okp
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2a_pc
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: penicillin  
Resistance TypeType: bl2b_ohio1
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2b_rob
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2b_tem
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2b_tem1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin_i  cephalosporin_ii  penicillin  
Resistance TypeType: bl2b_tem2
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin_i  cephalosporin_ii  penicillin  
Resistance TypeType: bl2b_tle
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2b_ula
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cephalosporin  penicillin  
Resistance TypeType: bl2be_ctxm
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: ceftazidime  cephalosporin_i  cephalosporin_ii  cephalosporin_iii  monobactam  penicillin  
Resistance TypeType: bl2be_k
Resistance: e_cephalosporin  monobactam  n_cephalosporin  penicillin  
Resistance TypeType: bl2be_men
Resistance: e_cephalosporin  monobactam  n_cephalosporin  penicillin  
Resistance TypeType: bl2be_oxy1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: monobactam  penicillin  
Resistance TypeType: bl2be_per
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: e_cephalosporin  monobactam  n_cephalosporin  penicillin  
Resistance TypeType: bl2be_shv2
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: e_cephalosporin  monobactam  n_cephalosporin  penicillin  
Resistance TypeType: bl2c_bro
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbenicillin  penicillin  
Resistance TypeType: bl2c_pse1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbenicillin  penicillin  
Resistance TypeType: bl2c_pse3
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbenicillin  penicillin  
Resistance TypeType: bl2d_lcr1
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_moxa
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa1
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa10
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa2
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa5
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_oxa9
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2d_r39
Description: Class D beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: cloxacillin  penicillin  
Resistance TypeType: bl2f_nmca
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  penicillin  
Resistance TypeType: bl2f_sme1
Description: Class A beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  penicillin  
Resistance TypeType: bl3_bc
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_ccra
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_cit
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_cpha
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_gim
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_imp
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_l
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_shw
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_sim
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: bl3_vim
Description: Class B beta-lactamase. This enzyme breaks the beta-lactam antibiotic ring open and deactivates the molecule's antibacterial properites.
Resistance: carbapenem  cephalosporin  cephamycin  penicillin  
Resistance TypeType: pbp1a
Description: The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Resistance: penicillin  
Resistance TypeType: pbp1b
Description: The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Resistance: penicillin  
Resistance TypeType: pbp2
Description: The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Resistance: penicillin  
Resistance TypeType: pbp2b
Description: The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Resistance: penicillin  
Resistance TypeType: pbp2x
Description: The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)
Resistance: penicillin  
Database LinksKEGG DRUG: D02405
ChEBI ID: CHEBI: 17334