| Antibiotic | chloramphenicol |
| Description | An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) |
| Action Target | 23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor |
| Synonyms | CP Chloromycetin Econochlor Amphicol |
| Resistance Type | Type: adeb
Require: adec adea
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: aminoglycoside chloramphenicol |
| Resistance Type | Type: adec
Require: adeb adea
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: aminoglycoside chloramphenicol |
| Resistance Type | Type: blt
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: chloramphenicol doxorubicin fluoroquinolone puromycin |
| Resistance Type | Type: bmr
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: chloramphenicol fluoroquinolone |
| Resistance Type | Type: cata1
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata10
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata11
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata12
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata13
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata14
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata15
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata16
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata2
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata3
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata4
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata5
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata6
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata7
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata8
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: cata9
Description: Group A chloramphenicol acetyltransferase, which can inactivate chloramphenicol.
Resistance: chloramphenicol |
| Resistance Type | Type: catb1
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol |
| Resistance Type | Type: catb2
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol |
| Resistance Type | Type: catb3
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol |
| Resistance Type | Type: catb4
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol |
| Resistance Type | Type: catb5
Description: Group B chloramphenicol acetyltransferase, which can inactivate chloramphenicol. Also referred to as xenobiotic acetyltransferase.
Resistance: chloramphenicol |
| Resistance Type | Type: ceoa
Require: ceob opcm
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: ceob
Require: opcm ceoa
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: cml_e1
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: cml_e2
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: cml_e3
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: cml_e4
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: cml_e5
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: cml_e6
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: cml_e7
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: cml_e8
Description: Major facilitator superfamily transporter, chloramphenicol efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: mdtl
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: mdtm
Description: Major facilitator superfamily transporter. Multidrug resistance efflux pump.
Resistance: acriflavine chloramphenicol norfloxacin |
| Resistance Type | Type: mexe
Require: mexf oprn
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol fluoroquinolone |
| Resistance Type | Type: mexf
Require: mexe oprn
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol fluoroquinolone |
| Resistance Type | Type: opcm
Require: ceob ceoa
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol |
| Resistance Type | Type: oprn
Require: mexf mexe
Description: Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.
Resistance: chloramphenicol fluoroquinolone |
| Database Links | KEGG DRUG: D00104
ChEBI ID: CHEBI: 17698 |
