ARDB-Antibiotic Resistance Genes Database

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Multidrug Transporters

The acquisition of multidrug resistance is a serious impediment to improved healthcare. Multidrug resistance is most frequently due to active transporters that pump a broad spectrum of chemically distinct, cytotoxic molecules out of cells, including antibiotics, antimalarials, herbicides and cancer chemotherapeutics in humans.Active membrane transporters, whatever their substrate, fall into a relatively small number of protein superfamilies which include four important distinct superfamilies: (1) the ABC family (ATP-binding cassette); (2) the MFS family (major facilitator superfamily); (3) the RND family (resistance-nodulation-division); (4) the SMR family (small multidrug resistance).

Here is a list of multidrug resistance transproters types